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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Heterogeneity of Oral Clefts in Relation to Associated Congenital Anomalies

Department of Human and Medical Genetics, Faculty of Medicine, Vilnius University
Centre for Medical Genetics, Vilnius University Hospital Santariškių Klinikos
Institute of Odontology, Faculty of Medicine, Vilnius University
Institute of Mathematics and Informatics, Vilnius University, Lithuania
Author to whom correspondence should be addressed.
Medicina 2013, 49(2), 11;
Received: 25 September 2012 / Accepted: 28 February 2013 / Published: 5 March 2013
Background and Objective. The first step in the search for the genetic basis of oral clefts should be the well-accepted classification and clinical data protocols, which are important in distinguishing separate phenotypic groups. The aim of this study was to compare the frequency of congenital malformations associated with oral clefts between the different groups of oral clefts.
Material and Methods
. The study population comprised 238 patients with oral clefts and one or more major congenital anomalies. All cases of oral clefts were subdivided into 2 groups: patients with the recognized conditions (n=97, 40.8%) and patients with the multiple congenital anomalies of unknown origin (n=141, 59.2%). The frequency of associated congenital anomalies was compared between the cleft palate (CP) and cleft lip and/or palate (CL/P) groups as well as between the cleft lip only (CL) and cleft lip with cleft palate (CLP) subgroups.
Results. A total of 420 anomalies associated with oral clefts were diagnosed in 141 patients with multiple congenital anomalies (2.98 anomalies per proband) with the highest incidence being in the CP group (3.5 anomalies per proband). Comparison of the CP and CL/P groups showed that some of associated congenital anomalies such as atresia and stenosis of the small intestine and micrognathia occurred significantly more often in the CP than CL/P group (2.1% vs. 0% and 3.5% vs. 1.1%; P<0.05). Meanwhile, comparison of the CL and CLP subgroups revealed accessory auricle, other specified anomalies of the ear, congenital anomalies of the circulatory system, and certain congenital musculoskeletal deformities of the spine to be more common in the CL than CLP group (5.1% and 0.5%, 11.9% and 5.1%, 3.4% and 0%, 3.4% and 0%, respectively; P<0.05).
. The highest incidence of associated congenital anomalies was in the CP group followed by the CL, CL/P, and CLP groups. Generally, the anomalies of the musculoskeletal system, cardiovascular system, and face including eye, ear, and neck were most common. The careful analysis of associated anomalies and cases of oral cleft subgroups with multiple congenital anomalies is helpful in identifying the etiologic entities and underscores the need for thorough evaluation and competent distinction of various types of oral clefts.
Keywords: oral clefts; associated congenital anomalies, cleft palate, cleft lip oral clefts; associated congenital anomalies, cleft palate, cleft lip
MDPI and ACS Style

Matulevičienė, A.; Preikšaitienė, E.; Linkevičienė, L.; Radavičius, M.; Molytė, A.; Utkus, A.; Kučinskas, V. Heterogeneity of Oral Clefts in Relation to Associated Congenital Anomalies. Medicina 2013, 49, 11.

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