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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Increased Use of Antidepressants in Wuhan, China: a Retrospective Study From 2006 to 2012

1
Department of Pharmacy, Wuhan Children’s Hospital, Wuhan, Hubei, China
2
Department of Pharmacy, Tongji Hospital, Wuhan, Hubei, China
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(12), 83; https://doi.org/10.3390/medicina49120083
Received: 26 November 2013 / Accepted: 30 December 2013 / Published: 4 January 2014
Objective. The aim of this study was to investigate the trend of antidepressant use and analyze the daily cost of antidepressants in Wuhan, China. Material and Methods. The data on the expenditure of antidepressants in Wuhan from 2006 to 2012 were retrospectively analyzed based on the defined daily dose (DDD) method recommended by the World Health Organization. In addition, the daily cost of antidepressants was calculated for the pharmacoeconomic evaluation.
Results
. The overall sales of antidepressants increased by 566.7% over the 7-year period. The utilization of antidepressants increased annually from 1.067 DDDs per 1000 inhabitants per day in 2006 to 4.144 in 2012. This upward trend was mainly driven by an increase in the use of selective serotonin reuptake inhibitors (SSRIs), which accounted for about 60% of antidepressant use. Notably, the use of traditional Chinese patent medicines (TCMs) approved to treat depression in China in 2010 increased from 0.158 DDDs per 1000 inhabitants per day in 2010 to 0.305 in 2012. The daily drug cost analysis indicated that selective serotonin and norepinephrine reuptake inhibitors (SNRIs) and other new antidepressants were more expensive while tricyclic and tetracyclic antidepressants (TCAs) had a low-cost advantage.
Conclusions
. Antidepressants were increasingly used over the study period. Among them, SSRIs followed by SNRIs were the most commonly used. After the approval for the treatment of depression, TCMs were generally accepted by physicians and patients. The low-cost advantage allowed TCAs to be used in the antidepressant therapy.
Keywords: antidepressant; daily drug cost; defined daily dose; selective serotonin reuptake inhibitors; traditional Chinese patent medicines antidepressant; daily drug cost; defined daily dose; selective serotonin reuptake inhibitors; traditional Chinese patent medicines
MDPI and ACS Style

Gao, P.; Zhang, H.; Xu, H.; Zhang, C.; Liu, D. Increased Use of Antidepressants in Wuhan, China: a Retrospective Study From 2006 to 2012. Medicina 2013, 49, 83.

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