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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Association Between Erectile Dysfunction and Asymptomatic Cardiovascular Damage in Middle-Aged Men

1
Clinic of Internal Medicine, Oncology and Family Medicine, Medical Faculty, Vilnius University
2
Clinic of Heart and Vascular Medicine, Medical Faculty, Vilnius University, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(12), 80; https://doi.org/10.3390/medicina49120080
Received: 29 July 2013 / Accepted: 30 December 2013 / Published: 4 January 2014
Background and Objective. It has been proposed that the same cardiovascular risk (CV) factors predispose middle-aged men to the development of both coronary artery disease and erectile dysfunction (ED). Moreover, several recently published studies have identified ED as a possible early marker of CV disease. The aim of this particular study was to evaluate the association between ED and early asymptomatic heart and vascular damage in middle-aged men with CV risk factors.
Material and Methods
. In this case-control study, the International Index of Erectile Function (IIEF) questionnaire was employed to assess the erectile function of the study participants and to allocate them either into the ED group (N=21; mean IIEF score, 18.15 [SD, 2.54]; mean age, 48.2 years [SD, 4.4]) or the control group (N=24; mean IIEF score, 23.45 [SD, 0.99]; mean age, 46.8 years [SD, 3.1]). Additionally, pulse wave velocity, augmentation index, pulse pressure, carotid intima media thickness (IMT), and atherosclerotic plaque count were determined, and echocardiography was performed in every subject.
Results
. The mean IMT and left ventricular mass index (LVMI) of both carotid arteries in the ED group were significantly higher when compared with controls (598.57 vs. 535.54 mm·10–3, P=0.03, and 107.26 vs. 98.67 g/m2, P=0.04, respectively). Using multiple regression analysis, an independent association between the IIEF score and the LVMI was found (P=0.002). No significant differences in the results of pulse wave velocity, atherosclerotic plaque count, and other laboratory tests were found between the 2 study groups.
Conclusions.
The study suggests that ED is associated with a higher LVMI and may be an early marker of CV disease.
Keywords: metabolic syndrome; pulse wave velocity; carotid artery intima media thickness; left ventricular mass index; erectile dysfunction metabolic syndrome; pulse wave velocity; carotid artery intima media thickness; left ventricular mass index; erectile dysfunction
MDPI and ACS Style

Dženkevičiūtė, V.; Petrulionienė, Ž.; Šapoka, V.; Kasiulevičius, V. Association Between Erectile Dysfunction and Asymptomatic Cardiovascular Damage in Middle-Aged Men. Medicina 2013, 49, 80.

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