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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessReview

Functional Significance of Microsatellite Markers

1
Genomics and Bioinformatics, Institute of Biology, University of Latvia
2
Faculty of Medicine, University of Latvia, Latvia
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Author to whom correspondence should be addressed.
Medicina 2013, 49(12), 79; https://doi.org/10.3390/medicina49120079
Received: 13 November 2013 / Accepted: 30 December 2013 / Published: 4 January 2014
The review summarizes literature data on the positive results of association studies between the length of microsatellite repeats and predisposition to pathologies. Actually, the data can be classified according to the localization of the microsatellite: in the gene promoter, in the part of exon 1 coding the signal sequence, in gene introns, in the coding areas of genes, and in 3'-untranslated regions. The functional significance of microsatellite length changes can be evaluated in many cases. The authors came up to the conclusion that further studies on microsatellite associations with diseases remain prospective as they reflect changes in the gene functional activity.
Keywords: microsatellite; human diseases; promoter; intron; exon microsatellite; human diseases; promoter; intron; exon
MDPI and ACS Style

Sjakste, T.; Paramonova, N.; Sjakste, N. Functional Significance of Microsatellite Markers. Medicina 2013, 49, 79.

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