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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Maternal Serum Soluble HLA-G Levels in Missed Abortions

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Department of Obstetrics and Gynecology, Faculty of Medicine, Duzce University
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Department of Obstetrics and Gynecology, Faculty of Medicine, Abant Izzet Baysal University
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Department of Obstetrics and Gynecology, Karacabey State Hospital
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Department of Obstetrics and Gynecology, Atatürk State Hospital
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Department of Biochemistry, Faculty of Medicine, Duzce University, Turkey
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(10), 68; https://doi.org/10.3390/medicina49100068
Received: 12 February 2013 / Accepted: 30 October 2013 / Published: 4 November 2013
Background and Objective. It is unclear how immune tolerance develops to a semiallograft fetus in pregnancy. Human leukocyte antigen G (HLA-G) expressed by extravascular trophoblasts plays an important role in the recognition of the gestational tissues as self and the development of immune tolerance against the gestational tissues by the maternal immune system. The soluble form of the HLA-G (sHLA-G) molecule in the maternal serum is also reported to contribute to the prevention of rejection during pregnancy. The aim of the study was to compare the maternal serum sHLA-G levels of the women with missed abortions and control subjects with uncomplicated pregnancies.
Material and Methods
. The prospective cross-sectional study involving 40 with missed abortions and 40 control women, matched by age, gestational age, and body mass index, was carried out. The study group consisted of the women with singleton pregnancies, who were diagnosed with a missed abortion. Only the patients who were confirmed to have an uncomplicated term delivery during follow-up were included in the control group. The serum sHLA-G level was compared between the groups.
Results. There was no significant difference in the mean serum sHLA-G levels in terms of gravidity (P=0.761) and a history of abortion (P=0.379) in the control group. The median serum sHLA-G level in the missed abortion group was significantly lower compared with the control group (16.8 [8.5–35.8] vs. 26 [11–135] U/mL, P<0.001). All the women in the control group had uncomplicated term deliveries.
Conclusion
. Our results showed that the women with missed abortions had significantly lower serum sHLA-G levels compared with the healthy pregnant controls, which may have potentially played a role in the impairment of physiological immunological tolerance during pregnancy. However, the determination of the exact role and the potential clinical utility of maternal serum sHLA-G for the detection/prediction of a missed abortion risk requires further detailed studies.
Keywords: pregnancy loss; sHLA-G; early pregnancy; missed abortion pregnancy loss; sHLA-G; early pregnancy; missed abortion
MDPI and ACS Style

Keskin, F.; Karatas, A.; Albayrak, M.; Bıyık, I.; Erkan, M.; Demirin, H.; Dilbaz, S. Maternal Serum Soluble HLA-G Levels in Missed Abortions. Medicina 2013, 49, 68.

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