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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Maternal Age-Associated Congenital Anomalies Among Newborns: A Retrospective Study in Latvia

by Irisa Zīle 1,2,* and 1
1
Department of Public Health and Epidemiology, Riga Stradins University, Latvia
2
Centre for Disease Prevention and Control, Department of Research and Statistics, Latvia
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(1), 6; https://doi.org/10.3390/medicina49010006
Received: 30 July 2012 / Accepted: 31 January 2013 / Published: 5 February 2013
Background and Objective. In Latvia, the mean age of women giving birth increased from 27.3 in 2000 to 29.0 years in 2010 during the last 11 years. The aim of this study was to report on major congenital anomalies of newborns at birth by the maternal age and to compare the mean maternal age by different diagnosis subgroups and maternal and neonatal characteristics.
Material and Methods
. A cross-sectional retrospective study with the data from the Medical Birth Register (2000–2010) was carried out. The live birth prevalence rate was calculated for the subgroups of major congenital anomalies per 10 000 live births by the maternal age.
Results
. The live birth prevalence rate of major congenital anomalies during the period 2000– 2010 was 211.4 per 10 000 live births. The prevalence rate increased depending on the maternal age. Congenital heart defects, limb defects, and urinary system anomalies were the most common anomalies. The study results showed an age-related risk of abdominal wall defects, orofacial clefts, and chromosomal anomalies. There were significantly higher proportions of preterm births, newborns with low birth weight, and complications during pregnancy among mothers aged 35 years and more.
Conclusions
. The data on congenital anomalies from the Latvian Medical Birth Register can be used for the assessment of epidemiology of congenital anomalies. The results of this retrospective study showed a decrease in the live birth prevalence rate of major congenital anomalies despite an increase in the mean age of mothers in Latvia.
Keywords: congenital anomalies; newborns; maternal age; prevalence rate congenital anomalies; newborns; maternal age; prevalence rate
MDPI and ACS Style

Zīle, I.; Villeruša, A. Maternal Age-Associated Congenital Anomalies Among Newborns: A Retrospective Study in Latvia. Medicina 2013, 49, 6.

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