Next Article in Journal
Susac’s Syndrome: A Case Presentation and Radiological Approach to this Rare Autoimmune Endotheliopathy
Previous Article in Journal
A Systematic Review of Phacoemulsification Cataract Surgery in Virtual Reality Simulators
Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Comparison of Changes in Blood Glucose, Insulin Resistance Indices, and Adipokine Levels in Diabetic and Nondiabetic Subjects With Morbid Obesity After Laparoscopic Adjustable Gastric Banding

1
Clinic of Internal Diseases, Family Medicine and Oncology, Faculty of Medicine, Vilnius University
2
Clinic of Gastroenterology, Nephrourology and Surgery, Faculty of Medicine, Vilnius University
3
Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Vilnius University, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2013, 49(1), 2; https://doi.org/10.3390/medicina49010002
Received: 19 October 2011 / Accepted: 21 January 2013 / Published: 26 January 2013
Objective. The aim of the study was to evaluate blood glucose, insulin resistance indices, and adipokine (leptin and adiponectin) levels in morbidly obese individuals with and without type 2 diabetes mellitus and to compare the changes in these parameters 1 year after laparoscopic adjustable gastric banding surgery.
Material and Methods
. In total, 103 patients (37 subjects with and 66 subjects without type 2 diabetes mellitus) were studied preoperatively and again 1 year after laparoscopic adjustable gastric banding.
Results
. One year after laparoscopic adjustable gastric banding, the leptin concentrations decreased significantly in both treatment groups, while the adiponectin levels increased significantly in the nondiabetic patients (11.19 μg/mL [SD 7.20] vs. 15.58 μg/mL [SD 7.8], P=0.003) and tended to increase in the group of the patients with type 2 diabetes mellitus (8.98 μg/mL [SD 6.80] vs. 13.01 μg/mL [SD 12.14], P>0.05). A considerable decrease in the insulin resistance indices was noted in the patients with type 2 diabetes mellitus 1 year after the intervention, and it was followed by a partial or complete remission of type 2 diabetes mellitus in 23 (85.19%) of the 27 investigated diabetic patients. The postoperative insulin resistance indices in the patients with type 2 diabetes mellitus became similar to the values in the nondiabetic subjects.
Conclusions
. Weight loss after laparoscopic adjustable gastric banding is associated with a significant increase in adiponectin secretion in nondiabetic morbidly obese patients and with improvement in adiponectin secretion in type 2 diabetes individuals. In subjects with type 2 diabetes, this surgical intervention results in a significant reduction in blood glucose and insulin resistance.
Keywords: adiponectin; leptin; laparoscopic adjustable gastric banding adiponectin; leptin; laparoscopic adjustable gastric banding
MDPI and ACS Style

Urbanavičius, V.; Abalikšta, T.; Brimas, G.; Abraitienė, A.; Gogelienė, L.; Strupas, K. Comparison of Changes in Blood Glucose, Insulin Resistance Indices, and Adipokine Levels in Diabetic and Nondiabetic Subjects With Morbid Obesity After Laparoscopic Adjustable Gastric Banding. Medicina 2013, 49, 2.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop