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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Volumetric MRI Assessment of Brain and Spinal Cord in Finnish Twins Discordant for Multiple Sclerosis

1
Department of Neurology and Rehabilitation, Tampere University Hospital
2
Department of Neurology, Kanta-Häme Central Hospital, Hämeenlinna
3
Department of Radiology, Regional Imaging Center, Tampere University Hospital
4
Research Unit, Pirkanmaa Hospital District
5
Tampere School of Public Health, University of Tampere
6
Medical School, University of Tampere, Finland
*
Author to whom correspondence should be addressed.
Medicina 2012, 48(9), 65; https://doi.org/10.3390/medicina48090065
Received: 28 May 2012 / Accepted: 30 September 2012 / Published: 5 October 2012
Background and Objective. Brain size, white matter hyperintensity, and the development of brain atrophy are known to be highly heritable. The decrease of brain volume starts from the very onset of multiple sclerosis and is 10-fold compared with normal aging. The aim of this study was to assess whether the brain and spinal cord volumes and the volume of white matter lesions differed between twins with multiple sclerosis and their asymptomatic co-twins.
Material and Methods. A co-twin control method was used to evaluate whether the brain and spinal cord volumes differ between twins with multiple sclerosis and their co-twins. Nineteen twin pairs were studied neurologically, and the volumes of T1, T2, FLAIR, and gadolinium-enhanced lesions and those of the brain and the spinal cord were obtained by magnetic resonance imaging. Results. Significant differences in the brain (P=0.064) or spinal cord (P=0.648) volumes were not detected. Four of the 7 monozygotic and 5 of the 12 dizygotic co-twins had focal brain white matter lesions, but none fulfilled the magnetic resonance imaging criteria of Barkhof. Spinal cord lesions were not seen in any of the co-twins.
Conclusions. The absence of a significant difference in the brain or spinal cord volume between the twins with multiple sclerosis and their co-twins supports the recent observation of brain size and the development of brain atrophy being highly heritable.
Keywords: multiple sclerosis; twins; brain atrophy; heritability; white matter; magnetic resonance imaging; volumetry multiple sclerosis; twins; brain atrophy; heritability; white matter; magnetic resonance imaging; volumetry
MDPI and ACS Style

Kuusisto, H.; Wu, X.; Dastidar, P.; Luukkaala, T.; Elovaara, I. Volumetric MRI Assessment of Brain and Spinal Cord in Finnish Twins Discordant for Multiple Sclerosis. Medicina 2012, 48, 65.

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