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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Behavioral Problems in Children with Benign Childhood Epilepsy With Centrotemporal Spikes Treated and Untreated with Antiepileptic Drugs

1
Clinic of Children’s Diseases, Vilnius University
2
Children’s Neurology Department, Children’s Hospital, Affiliate of Vilnius University Hospital Santariškių Klinikos
3
Department of Mathematical Statistics, Faculty of Fundamental Sciences, Vilnius Gediminas Technical University
4
Department of Neurology, Lithuanian University of Health Sciences, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2012, 48(7), 50; https://doi.org/10.3390/medicina48070050
Received: 15 September 2011 / Accepted: 24 July 2012 / Published: 29 July 2012
The aim of this study was to investigate behavioral problems in two groups of children with benign childhood epilepsy with centrotemporal spikes (BECTS), i.e., those treated with antiepileptic drugs and those not treated in order to identify the factors associated with behavioral problems.
Material and Methods
. In total, 20 newly diagnosed untreated, 23 treated patients with BECTS, and 20 patients with acute/subacute peripheral nervous system disorders as a comparison group (aged 6–11 years) were examined. The evaluation was performed using the Lithuanian version of the Child Behavior Checklist (CBCL). Schooling parameters, clinical parameters, EEG parameters, and their relation to the results of the CBCL were also investigated.
Results
. The treated patients with BECTS had significantly higher scores in the subscales of Social Problems, Anxious/Depressed, Aggressive Behavior, and Attention Problems compared with the scores of the patients with peripheral nervous system disorders. A significant relationship was established between the scores of native language grades and Attention Problems; grades in mathematics and treatment duration; and age when the first seizure occurred and Delinquent Behavior in the group of treated patients. The duration of epilepsy was positively correlated with the scores in the subscales of Withdrawn and Delinquent Behavior. The presence of additional extrarolandic focus and spread of focal specific discharges to the centrofrontotemporal and centroparietotemporal areas were related to higher scores in Social Problems, Attention Problems, and Delinquent Behavior in the group of the treated patients with BECTS.
Conclusions
. Children with BECTS, especially those treated and with a longer epilepsy course, were found to be at risk of behavioral problems. Lower grades were associated with a longer disease course and medications. The presence of extrarolandic discharges was related to higher CBCL scores in the group of the treated patients with BECTS.
Keywords: treatment; benign childhood epilepsy with centrotemporal spikes; epilepsy; behavioral problems; seizures treatment; benign childhood epilepsy with centrotemporal spikes; epilepsy; behavioral problems; seizures
MDPI and ACS Style

Samaitienė, R.; Norkūnienė, J.; Jurkevičienė, G.; Grikinienė, J. Behavioral Problems in Children with Benign Childhood Epilepsy With Centrotemporal Spikes Treated and Untreated with Antiepileptic Drugs. Medicina 2012, 48, 50.

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