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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The First Evidence of Hereditary and Familial Gastric Cancer in Latvia: Implications for Prevention

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Department of Surgery, Rīga Stradiņš University
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Department of Pathology, Rīga Stradiņš University, Latvia
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Author to whom correspondence should be addressed.
Medicina 2012, 48(6), 47; https://doi.org/10.3390/medicina48060047
Received: 29 February 2012 / Accepted: 27 March 2012 / Published: 1 April 2012
Background and Objective. Gastric cancer is a frequent cause of cancer mortality. The prognosis of established tumor is unfavorable due to the propensity to spread and limited treatment efficiency. Therefore, prevention has a high significance. We tested a population screening approach in order to identify families with an increased gastric cancer load for further surveillance.
Material and Methods
. Population screening was performed by questionnaire reaching 76.6% of the population. Hereditary gastric cancer (HGC) syndrome was diagnosed if 3 mutually first-degree relatives with gastric cancer were reported in the kindred. Additional group (HGC2) of families with 2 first-degree relatives affected by gastric cancer was identified.
Results. The HGC syndrome was diagnosed in 0.11%, but HGC2 syndrome, in 0.4% probands. The gastric cancer frequency among blood relatives was 25.2% (95% CI, 20.6%–30.4%) in HGC, but 16.0% (95% CI, 13.8%–18.5%) in HGC2 families. The mean age at diagnosis of cancer was 56.9 years (95% CI, 53.4–60.3) in HGC and 62.5 years (95% CI, 60.1–64.8) in HGC2. The mean survival was 2.6 years (95% CI, 1.2–4.0).
Conclusions. Population screening identifies reasonable number of families with a high frequency of gastric cancer. The frequency of gastric cancer and an unfavorable course characterized by low survival justify surveillance in families with 2 or 3 first-degree relatives affected by gastric cancer. Population screening provides the age characteristics of the respective tumors in order to adjust the surveillance schedule.
Keywords: hereditary gastric cancer; familial gastric cancer; hereditary cancer; population screening hereditary gastric cancer; familial gastric cancer; hereditary cancer; population screening
MDPI and ACS Style

Vanags, A.; Štrumfa, I.; Gardovskis, A.; Āboliņš, A.; Simtniece, Z.; Trofimovičs, G.; Gardovskis, J. The First Evidence of Hereditary and Familial Gastric Cancer in Latvia: Implications for Prevention. Medicina 2012, 48, 47.

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