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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Anemia as a Complication of Parvovirus B19 Infection in Renal Transplant Recipients

August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University
Latvian Transplantology Center, P. Stradins Clinical University Hospital, Latvia
Author to whom correspondence should be addressed.
Medicina 2012, 48(6), 44;
Received: 20 January 2012 / Accepted: 22 June 2012 / Published: 27 June 2012
Background. The frequency of B19 infection in renal transplant donors and recipients was studied to determine the significance of active viral infection in the development of anemia.
Material and Methods. Serum, plasma, and peripheral blood leukocyte samples of 47 renal transplant donors, 38 recipients with anemia (Group 1), and 25 without anemia (Group 2) after renal transplantation were evaluated for the presence of anti-B19 specific antibodies (ELISA) and B19 DNA (nPCR).
Results. Active persistent B19 infection after renal transplantation was detected in 12 of the 38 in the Group 1 (10 had reactivation and 2 primary infection), and none of the recipients in the Group 2 had it. Of the 12 recipients in the Group 1, 10 were seropositive and 2 seronegative before renal transplantation; 10 received the transplants from the seropositive and 2 from seronegative donors. rHuEPO therapy-resistant severe anemia was detected only in the recipients with active B19 infection after renal transplantation in the Group 1 (7/12). The logistic regression analysis revealed a significant relationship between active B19 infection and severe anemia (OR, 0.039; 95% CI, 0.006–0.257; P=0.001).
. Active B19 infection was documented only in the anemic recipients and could be associated with the development of severe anemia after renal transplantation. This allows us to recommend concurrent screening for viral DNA in plasma and detection of anti-B19 IgM class antibodies. To find the association between B19 infection and the development of anemia, further investigations are necessary.
Keywords: anemia; renal transplantation; B19 infection anemia; renal transplantation; B19 infection
MDPI and ACS Style

Čapenko, S.; Kozireva, S.; Folkmane, I.; Bernarde, K.; Rozentāls, R.; Murovska, M. Anemia as a Complication of Parvovirus B19 Infection in Renal Transplant Recipients. Medicina 2012, 48, 44.

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