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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Postoperative Survival in Patients With Multiple Brain Metastases

Neurosurgery Department, Riga East Clinical University Hospital “Gailezers,” Latvia
Author to whom correspondence should be addressed.
Medicina 2012, 48(6), 41;
Received: 27 January 2012 / Accepted: 12 June 2012 / Published: 17 June 2012
Background and Objective. Although surgery is traditionally performed for patients with a single brain metastasis, an increasing number of patients with multiple brain metastases may also be treated surgically. The objective of the study was to analyze postoperative survival results and the clinical factors affecting these results.
Material and Methods
. The records of the patients who underwent surgical resection of 2 or more lesions between January 2005 and January 2010 were retrospectively reviewed. Survival was calculated from the date of surgery to the last follow-up evaluation or death, and different clinical factors were analyzed in regard to patient survival.
. In total, 36 patients underwent one or more craniotomies. The survival of the total group ranged from 16 days to 37.5 months (mean, 29 months). There were 4 deaths within 30 days. When divided into Radiation Therapy Oncology Group RPA classes, the survival time was 11.75, 8.58, and 5.31 months for classes 1, 2, and 3, respectively. Regarding an impact on the survival, a significant association with a favorable outcome was found for the following factors: the number of brain metastases (2–3 vs. 4–6, P=0.046), RPA classes (1 vs. 2 or 3, P=0.0192), and extent of metastasis resection (all vs. partial, P=0.018).
Conclusions. Well-selected patients with multiple brain metastases appear to benefit from surgery compared with historical controls of patients treated with whole-brain radiotherapy alone.
Keywords: multiple brain metastases; surgery, survival multiple brain metastases; surgery, survival
MDPI and ACS Style

Auslands, K.; Apškalne, D.; Bicāns, K.; Ozols, R.; Ozoli, H. Postoperative Survival in Patients With Multiple Brain Metastases. Medicina 2012, 48, 41.

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