A Meta-Analysis of the Relationship Between NAT 2 Polymorphism and Colorectal Cancer Susceptibility
Material and Methods. Relevant studies that had investigated NAT2 polymorphism and CRC susceptibility were identified through a comprehensive search of Pubmed, EMBASE, Medline, Biosis, Wiley-Blackwell, ISI Web of Knowledge, CNKI, and Chinese Biomedicine Database until October 2011. After selection based on the inclusion and exclusion criteria, the relevant data were extracted from each study, and finally a meta-analysis was performed.
Results. Eight phenotype studies (791 cases and 1158 controls) and 45 genotype studies (13 875 cases and 18 879 controls) were included in the present meta-analysis. The pooling of phenotype studies showed no significant association between the NAT2 acetylator status and CRC susceptibility (rapid acetylator, OR, 1.32; 95% CI, 0.92–1.89, P=0.14; slow acetylator, OR, 0.76; 95% CI, 0.53–1.09, P=0.14). The combined ORs for rapid and slow acetylator status and CRC risk in genotype studies were 1.01 (95% CI, 0.94–1.08; P=0.86) and 0.99 (95% CI, 0.93–1.06; P=0.86), respectively. In the subgroup analysis by regions, no increased risks were found in Asians, Europeans, Americans, or Australasians. Pooling studies were also conducted on the groups of gender, specific tumor sites, and smoking status, but no significant association in genotype distribution between CRC and control was found as well.
Conclusions. These results of our meta-analysis suggest that there is no overall association between NAT2 polymorphism and CRC susceptibility.
Liu, H.; Fu, Z.-X.; Wang, C.-Y.; Qian, J.; Xing, L.; Liu, Y.-W. A Meta-Analysis of the Relationship Between NAT 2 Polymorphism and Colorectal Cancer Susceptibility. Medicina 2012, 48, 17.
Liu H, Fu Z-X, Wang C-Y, Qian J, Xing L, Liu Y-W. A Meta-Analysis of the Relationship Between NAT 2 Polymorphism and Colorectal Cancer Susceptibility. Medicina. 2012; 48(3):17.Chicago/Turabian Style
Liu, Hong; Fu, Zhong-xue; Wang, Chun-yi; Qian, Jiang; Xing, Lei; Liu, Yi-wu. 2012. "A Meta-Analysis of the Relationship Between NAT 2 Polymorphism and Colorectal Cancer Susceptibility." Medicina 48, no. 3: 17.