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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Evaluation of Health-Related Quality of Life in Lithuanian Brain Tumor Patients Using the EORTC Brain Cancer Module

1
Department of Neurosurgery, Medical Academy, Lithuanian University of Health Sciences
2
Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences
3
Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2012, 48(11), 86; https://doi.org/10.3390/medicina48110086
Received: 11 June 2012 / Accepted: 28 December 2012 / Published: 2 January 2013
Background and Objective. Health-related quality of life (HRQoL) is considered an important outcome measure in neuro-oncology. The aim of this study was to evaluate the psychometric properties of the brain cancer-specific Quality of Life Questionnaire (QLQ-BN20) of the European Organization for Research and Treatment of Cancer (EORTC) in Lithuanian brain tumor patients.
Material and Methods
. One hundred consecutive patients (71% of women; mean age, 58±14 years) admitted for elective brain tumor surgery were evaluated for HRQoL using the QLQ-BN20, QLQ-C30 (a core EORTC questionnaire for cancer patients), and SF-36 scale; for motor dysfunction (clinical examination); for cognitive dysfunction (Mini-Mental State Examination); and for disability (Barthel Index).
Results
. The QLQ-BN20 subscales had an adequate internal consistency (Cronbach α, 0.75– 0.90). Motor dysfunction on neurological examination was associated with greater motor dysfunction on the QLQ-BN20; greater disability, with greater future uncertainty, motor dysfunction, communication deficits, headaches, seizures, drowsiness, itchy skin, weakness of legs, and poor bladder control on the QLQ-BN20; and cognitive dysfunction, with greater future uncertainty, visual deficits, motor dysfunction, communication deficits, headaches, drowsiness, and weakness of legs symptoms on the QLQ-BN20, suggesting an adequate clinical validity of the QLQ-BN20. A score for motor dysfunction on the QLQ-BN20 correlated with a score for motor dysfunction on the QLQ-C30 and SF-36 scales; a score for headache on the QLQ-BN20, with a score for pain on the QLQ-C30 and SF-36 scales; and a score for drowsiness symptoms on the QLQ-BN20, with a score for fatigue on the QLQ-C30.
Conclusions
. The Lithuanian version of the EORTC-QLQ-BN20 scale has acceptable psychometric properties and can be reliably used for the assessment of HRQoL in brain tumor patients.
Keywords: brain tumor; health-related quality of life; validity; reliability brain tumor; health-related quality of life; validity; reliability
MDPI and ACS Style

Bunevičius, A.; Tamašauskas, Š.; Tamašauskas, A.; Deltuva, V. Evaluation of Health-Related Quality of Life in Lithuanian Brain Tumor Patients Using the EORTC Brain Cancer Module. Medicina 2012, 48, 86.

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