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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Tear Nitric Oxide Levels in Behçet’s Disease

Department of Ophthalmology, Batman State Hospital
Department of Ophthalmology, Bakırköy Training and Research Hospital
Department of Ophthalmology, Cerrahpaşa Medical School, İstanbul University
Department of Medical Biology, Haseki Training and Research Hospital, Turkey
Authors to whom correspondence should be addressed.
Medicina 2012, 48(11), 81;
Received: 18 May 2012 / Accepted: 30 November 2012 / Published: 5 December 2012
The aim of this study was to evaluate the tear nitric oxide (NO) level in patients with Behçet’s disease and to compare it with that in healthy subjects. Material and Methods. The subjects were divided into 3 groups: the active disease, inactive disease, and control groups. NO concentrations were determined by a nitrate/nitrite colorimetric assay kit and measured spectrophotometrically at 540 nm.
. The tear nitrate/nitrite levels were 0.06 nmol/μL (SD, 0.05) in the active disease group, 0.05 nmol/μL (SD, 0.05) in the inactive disease group, and 0.02 nmol/μL (SD, 0.01) in the control group. The tear nitrate/nitrite levels of both active and inactive groups were higher than those of the control group (P=0.001 and P=0.047, respectively), but there was no significant difference between the active and inactive groups.
Conclusion. Our results demonstrated that the tear NO levels were elevated in the patients with Behçet’s disease. We imply that a better understanding of NO function in the pathogenesis of Behçet uveitis is necessary to develop new therapies based on the inhibitors of NO synthases.
Keywords: Behçet’s disease; nitric oxide; uveitis Behçet’s disease; nitric oxide; uveitis
MDPI and ACS Style

İşcan, Y.; Yiğit, U.; Tuğcu Çakmak, B.; Erdoğan, M.; Erdoğan, D.A.; Öner, V.; Taş, M.; Özyazgan, Y. Tear Nitric Oxide Levels in Behçet’s Disease. Medicina 2012, 48, 81.

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