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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Executive Functions in Adolescents With Idiopathic Generalized Epilepsy

1
Department of Neurology, Medical Academy, Lithuanian University of Health Sciences
2
Department of Psychiatry, Medical Academy, Lithuanian University of Health Sciences, Lithuania
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Author to whom correspondence should be addressed.
Medicina 2011, 47(6), 44; https://doi.org/10.3390/medicina47060044
Received: 14 April 2011 / Accepted: 22 June 2011 / Published: 27 June 2011
Disorders of executive functioning have recently been reported in patients with juvenile myoclonic epilepsy (JME); however, data on other syndromes of generalized idiopathic epilepsy (IGE) other than JME, especially in adolescence, are scarce. The aim of this study was to explore specific executive functions in a group of adolescents with IGE of short duration and to evaluate the possible factors that might influence these functions.
Material and Methods
. Neuropsychological investigation of executive functions (the Verbal Fluency Test, the Five-Point Test, the Trail-Making Test, and the Stroop test) was performed in 59 patients aged 14–17 years and meeting the diagnostic criteria for IGE, and in the group of 59 agematched controls without any history of epilepsy.
Results
. The IGE group subjects scored worse than the controls in most of the executive function tests: phonemic (P=0.008) and semantic (P=0.001) word fluency, figural fluency (P=0.008), visual search and sequencing of numbers (P=0.001), and alternate number-letter sequencing (P=0.018). None of the test scores differed between the new-onset and the established IGE groups, or between the groups of cases with and without myoclonias. No relationship between executive functioning and gender, age, duration or activity of epilepsy, treatment, or epileptiform discharges on electroencephalography was found.
Conclusions. Executive dysfunction was present in adolescents with JME and other syndromes of IGE, manifesting with generalized tonic-clonic seizures without myoclonias, despite short duration and benign course of epilepsy
Keywords: idiopathic generalized epilepsy; executive functions; myoclonias; generalized tonicclonic seizures idiopathic generalized epilepsy; executive functions; myoclonias; generalized tonicclonic seizures
MDPI and ACS Style

Gelžinienė, G.; Jurkevičienė, G.; Marmienė, V.; Adomaitienė, V.; Endzinienė, M. Executive Functions in Adolescents With Idiopathic Generalized Epilepsy. Medicina 2011, 47, 44.

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