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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Changes in Antibiotic Resistance Level of Nosocomial Pseudomonas Aeruginosa Isolates in the Largest University Hospital of Lithuania

1
Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences
2
Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences
3
Department of Laboratory Medicine, Medical Academy, Medicine of Lithuanian University of Health Sciences, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2011, 47(5), 39; https://doi.org/10.3390/medicina47050039
Received: 4 April 2011 / Accepted: 18 May 2011 / Published: 23 May 2011
The aim was to estimate changes in the resistance rates of Pseudomonas aeruginosa (P. aeruginosa) strains isolated from patients treated in intensive care units of the largest university hospital.
Materials and Methods
. Isolates were identified with the Phoenix ID system (Becton Dickinson, USA). The minimum inhibitory concentration (MIC) of ceftazidime, ciprofloxacin, and amikacin were determined by the E-test and evaluated following the recommendations of the Clinical Laboratory Standards Institute.
Results. In 2003, the proportion of P. aeruginosa strains resistant to piperacillin was greatest followed by strains resistant gentamicin and ciprofloxacin. In 2008, the resistance rates markedly changed being the highest to ciprofloxacin. An increase in the resistance rates to ciprofloxacin (+24%, P<0.001) and ceftazidime (+8.3%, P<0.05) was documented. In 2003, there were 66.7% of P. aeruginosa strains sensitive to all antibiotics tested, and this percentage decreased to 47.5% in 2008 (P<0.05). During the study, a significant increase in the median MICs for ciprofloxacin and amikacin was observed (P<0.001); however, no significant change was documented for ceftazidime.
Conclusions
. P. aeruginosa remains an important nosocomial pathogen with relatively high overall resistance to antimicrobial agents, and the resistance level is increasing.
Keywords: resistance level of Pseudomonas aeruginosa to antibiotics; multidrug resistance; minimum inhibitory concentration resistance level of Pseudomonas aeruginosa to antibiotics; multidrug resistance; minimum inhibitory concentration
MDPI and ACS Style

Adukauskienė, D.; Vitkauskaitė, A.; Skrodenienė, E.; Dambrauskienė, A.; Vitkauskienė, A. Changes in Antibiotic Resistance Level of Nosocomial Pseudomonas Aeruginosa Isolates in the Largest University Hospital of Lithuania. Medicina 2011, 47, 39.

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