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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study

1
Division of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Cottingham, United Kingdom
2
Technostics Limited, The Deep Business Centre, Kingston upon Hull, United Kingdom
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Author to whom correspondence should be addressed.
Medicina 2011, 47(4), 28; https://doi.org/10.3390/medicina47040028
Received: 22 November 2010 / Accepted: 18 April 2011 / Published: 23 April 2011
Background and Objective. Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. There is evidence of the increased prevalence of gastroesophageal reflux disease in patients with IPF. The aim of this prospective study was to evaluate reflux in patients with IPF by analyzing the scores of the reflux cough questionnaire, measurement of pepsin in exhaled breath condensate (EBC) to detect extraesophageal reflux, and Helicobacter pylori serology to evaluate the prevalence of this stomach bacterium in patients with IPF.
Material and Methods.
The Hull airway reflux questionnaire (HARQ) was completed by 40 patients with IPF and 50 controls in order to evaluate reflux symptoms. EBC was collected from 23 patients (17 patients with IPF and 6 controls) for measurement of pepsin by the lateral flow technique. A prospective study of 57 subjects (34 patients with IPF and 23 controls) for H. pylori antibody detection by ELISA was performed.
Results
. Significantly higher HARQ scores (maximum score, 70) were recorded in patients with IPF compared with controls (19.6 [SD, 12.4] vs. 3 [SD, 2.9], P<0.001). There was no significant difference in EBC pepsin positivity between patients with IPF and controls (2 of the 17 patients vs. none of the 6 controls, P=0.38). There was no significant difference in H. pylori serology between patients with IPF and controls (17 of the 34 patients vs. 14 of the 23 controls, P=0.42).
Conclusion. Patients with IPF had significantly increased scores of airway reflux symptoms. However, no objective evidence of extraesophageal reflux or H. pylori infection in patients with IPF was obtained in this study. The role of gastroesophageal and extraesophageal reflux in pathogenesis of IPF should be evaluated in a larger prospective study.
Keywords: idiopathic pulmonary fibrosis; gastroesophageal reflux; exhaled breath condensate; Helicobacter pylori idiopathic pulmonary fibrosis; gastroesophageal reflux; exhaled breath condensate; Helicobacter pylori
MDPI and ACS Style

Fahim, A.; Dettmar, P.W.; Morice, A.H.; Hart, S.P. Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study. Medicina 2011, 47, 28.

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