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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The Relationship Between Seropositivity Against Chlamydia pneumoniae and Stroke and its Subtypes in a Latvian Population

Department of Neurology, Riga Stradins University, 2Clinic of Neurology, Paula Stradins University Hospital, Latvia
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Author to whom correspondence should be addressed.
Medicina 2011, 47(12), 96; https://doi.org/10.3390/medicina47120096
Received: 19 April 2010 / Accepted: 30 December 2011 / Published: 4 January 2012
Background and Objective. Serological evidence of infection with Chlamydia pneumoniae has been associated with cardiovascular diseases, but the relationship with stroke and its risk factors remains not completely understood. The aim of this study was to determine whether serological evidence of infection with Chlamydia pneumoniae was associated with the risk of ischemic stroke and any of investigated stroke subtypes.
Material and Methods. Confirmed stroke cases (n=102) were compared with gender- and agematched control patients (n=48). The patients with stroke were divided into 3 groups according to the TOAST criteria: atherothrombotic (n=36), cardioembolic (n=47), and of undetermined etiology (n=19). Plasma levels of IgG antibodies to Chlamydia pneumoniae were measured by enzymelinked immunosorbent assay.
Results. There was a significant association between seropositivity to Chlamydia pneumoniae and stroke. Anti-Chlamydia pneumoniae IgG antibodies were detected in 64 case patients (62.7%) and 17 control patients (35.4%) (χ2=9.8; df=1; P=0.002). IgG seropositivity to Chlamydia pneumoniae was linked to all the analyzed etiological subtypes of stroke.
Conclusion
. This study showed that IgG seropositivity to Chlamydia pneumoniae was associated with stroke and all the analyzed etiological subtypes of stroke.
Keywords: cerebrovascular disease; stroke; Chlamydia pneumoniae; risk factor cerebrovascular disease; stroke; Chlamydia pneumoniae; risk factor
MDPI and ACS Style

Ķēniņa, V.; Auce, P.; Priede, Z.; Millers, A. The Relationship Between Seropositivity Against Chlamydia pneumoniae and Stroke and its Subtypes in a Latvian Population. Medicina 2011, 47, 96.

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