Human Herpesvirus 6 and 7 Reactivation and Disease Activity in Multiple Sclerosis
Material and Methods. The frequency of plasma viremia by nested polymerase chain reaction and transcription of viral mRNA in peripheral blood mononuclear cells by reverse transcriptasepolymerase chain reaction (RT-PCR) of 14 relapsing/remitting (RR) and 14 secondary progressive (SP) MS patients were studied in comparison with clinical manifestation of the disease. Serum concentrations of cytokines IL-12 and TNF-α were analyzed by enzyme-linked immunosorbent assay.
Results. Plasma samples from 25 of the 28 MS patients with estimated latent/persistent HHV-6 and/or HHV-7 infection were examined during relapse and remission/relative remission. HHV-6 reactivation was found in 4 of the 7 RRMS and 4 of the 7 SPMS patients, and HHV-7 reactivation was identified in 3 of the 7 RRMS and 1 of the 7 SPMS patients (all in relapse). In 2 of the 3 RRMS patients without viremia in relapse, HHV-6 mRNA transcription was detected. In RRMS and SPMS patients with active HHV-6 and HHV-7 infection in relapse, the serum concentrations of IL-12 and TNF-α were significantly higher than in those with latent virus infection.
Conclusions. HHV-6 and HHV-7 reactivation could be implicated in the exacerbation of MS via activation of Th1 lymphocyte subsets.
Nora-Krukle, Z.; Chapenko, S.; Logina, I.; Millers, A.; Platkajis, A.; Murovska, M. Human Herpesvirus 6 and 7 Reactivation and Disease Activity in Multiple Sclerosis. Medicina 2011, 47, 75.
Nora-Krukle Z, Chapenko S, Logina I, Millers A, Platkajis A, Murovska M. Human Herpesvirus 6 and 7 Reactivation and Disease Activity in Multiple Sclerosis. Medicina. 2011; 47(10):75.Chicago/Turabian Style
Nora-Krukle, Zaiga; Chapenko, Svetlana; Logina, Inara; Millers, Andrejs; Platkajis, Ardis; Murovska, Modra. 2011. "Human Herpesvirus 6 and 7 Reactivation and Disease Activity in Multiple Sclerosis." Medicina 47, no. 10: 75.