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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Hospitalized Adult Patients with 2009 Pandemic Influenza A (H1N1) in Kaunas, Lithuania

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Department of Infectious Diseases, Medical Academy, Lithuanian University of Health Sciences
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Department of Radiology, Medical Academy, Lithuanian University of Health Sciences
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Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences
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Department of Anesthesiology, Medical Academy, Lithuanian University of Health Sciences
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Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences
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Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences
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Department of Dental and Oral Pathology, Medical Academy, Lithuanian University of Health Sciences
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Intensive Care Unit, Kaunas Hospital, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2011, 47(1), 11-18; https://doi.org/10.3390/medicina47010002
Received: 20 October 2010 / Accepted: 6 January 2011 / Published: 11 January 2011
The objective of this study was to identify case characteristics and clinical course of the disease in patients hospitalized with 2009 pandemic influenza A (H1N1) infection during the first wave of the pandemic and to identify risk factors associated with the complicated course of illness. Material and methods. A retrospective study of adult cases of the laboratory-confirmed 2009 pandemic influenza A (H1N1) virus admitted to three hospitals in Kaunas between November 1, 2009, and March 15, 2010, was carried out. The main outcome measures were clinical characteristics, risk factors for complicated disease, treatment, and clinical course of the disease. Results. The study enrolled 121 of the 125 patients hospitalized due to 2009 pandemic influenza A (H1N1) virus infection. The median age was 31 years (range, 18–83); 5% of the patients were aged more than 65 years. Pregnant and postpartum women comprised 26% of all hospitalized cases. Nearly half (49.5%) of those who underwent chest radiography had findings consistent with pneumonia, which was bilateral in one-third of cases. The risk to have pandemic influenza complicated by pneumonia increased significantly with one-day delay from symptom onset to antiviral treatment (OR, 2.241; 95% CI, 1.354–3.710). More than half (57%) of the patients received antiviral treatment. In 45% of the treated patients, antiviral drugs were administered within 48 hours from symptom onset. Intensive care was required in 7.4% of the cases. The overall mortality was 5% (6/121). The median age of the patients who died was 43.5 years (range, 23–62); 4 patients had been previously healthy, 1 patient suffered from chronic lympholeukemia, and 1 patient was a pregnant woman. Conclusion. The 2009 pandemic influenza A (H1N1) caused considerable morbidity in a significant proportion of hospitalized adults. The main risk factor associated with the complicated course of illness was delayed antiviral treatment.
Keywords: influenza A (H1N1); risk factors; pregnancy; complications; pneumonia influenza A (H1N1); risk factors; pregnancy; complications; pneumonia
MDPI and ACS Style

Mickienė, A.; Daniusevičiūtė, L.; Vanagaitė, N.; Vėlyvytė, D.; Blauzdžiūnienė, O.; Nadišauskienė, R.; Macas, A.; Sakalauskas, R.; Pilvinis, V.; Nedzelskienė, I.; Jodžiūnienė, L. Hospitalized Adult Patients with 2009 Pandemic Influenza A (H1N1) in Kaunas, Lithuania. Medicina 2011, 47, 11-18.

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