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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Prevalence of human papillomavirus types in cervical intraepithelial lesions

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Institute of Oncology, Vilnius University
2
Clinic of Obstetrics and Gynecology, Faculty of Medicine, Vilnius University
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Vilnius University Hospital Santariðkiø Klinikos
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Clinic of Internal Medicine, General Practice and Oncology, Faculty of Medicine, Vilnius University
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Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2010, 46(9), 616; https://doi.org/10.3390/medicina46090087
Received: 8 September 2009 / Accepted: 6 September 2010 / Published: 11 September 2010
Background. Since the implementation of the cervical cancer screening program in Lithuania in 2004, cervical cancer incidence rates have stabilized during a 4-year period: in 2006 and 2007, 508 and 485 new cases, respectively, were diagnosed. Human papillomavirus (HPV) infection is one of the main risk factors for cervical cancer and development of intraepithelial lesions. However, not only HPV, but also HPV type, is a very important factor for malignant transformation. Cervical intraepithelial lesions with HPV 16 and 18 more frequently progress to cancer. To date, in Lithuania, studies only on HPV prevalence and risk factors have been carried out, and less attention has been paid to the identification of HPV types. The aim of this study was to identify the most common HPV types in women with various cytological lesions.
Material and methods. A total of 246 women with various cytological lesions (atypical squamous cells of undetermined significance [ASCUS], low-grade squamous intraepithelial lesion [LSIL], and high-grade squamous intraepithelial lesion [HSIL]) were included into the study. All the women were screened for HPV infections followed by HPV typing for types 6, 11, 16, 18, 31, 33, 45, and 59. Polymerase chain reaction was used.
Results. Less than half (45.5%) of women with cytological lesions were infected with HPV. The highest prevalence of HPV was detected in women with HSILs (62.1%) and CIN2 (86.7%). HPV typing revealed that the most frequent type was HPV 16 (64.3%); HPV 18 and HPV 33 accounted for 5.4% and 4.5% of cases, respectively. Based on cytologic diagnosis, HPV 16 was more frequently found in women with HSILs than women with ASCUS (77.8% vs. 50.0%).
Conclusions. The prevalence of HPV infection in women with cytological lesions was 45.5%. The highest prevalence of HPV was detected in women with HSILs (cytologic investigation) and CIN2 (histologic investigation). HPV 16 is the most common type in women with various cervical intraepithelial lesions.
Keywords: cervical intraepithelial lesions; prevalence of human papillomavirus types cervical intraepithelial lesions; prevalence of human papillomavirus types
MDPI and ACS Style

Gudlevièienë, Þ.; Ðepetienë, A.; Didþiapetrienë, J.; Valuckas, K.P.; Smailytë, G.; Dràsutienë, G.; Nadiðauskienë, R.J. Prevalence of human papillomavirus types in cervical intraepithelial lesions. Medicina 2010, 46, 616.

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