Linear and nonlinear heart rate dynamics in elderly inpatients. Relations with comorbidity and depression
Material and methods. Twenty-six subjects (aged 78±9 years) were recruited from the Short- Term Stay Unit at the Hospital General de Alicante. Before joining a Physical Activity Program aimed to prevent functional impairment and after medical selection and written consent, inpatients were tested for heart rate variability, Yesavage Geriatric Depression Scale, and Charlson comorbidity index score.
Results. Men compared to women showed a signifi cantly larger CCI score. Short-term scaling exponent (α1), derived from detrended fl uctuation analysis, showed a negative correlation with Charlson comorbidity index. Conversely, a positive correlation was found between sample entropy (SampEn) and Yesavage Scale.
Conclusions. On the one hand, fractal analysis of HRV confirms to be useful as a risk stratifier tool. On the other hand, SampEn is proposed to be reflecting a non-neurally generated complexity when accompanied with low values of α1. Accordingly, in this regime, it would be indicative of a paradoxical gradual reduction in cardiac autonomic control, accentuated with the severity of depressive symptoms.
Blasco-Lafarga, C.; Martínez-Navarro, I.; Sisamón, M.E.; Caus, N.; Yangüez, E.; Llorens-Soriano, P. Linear and nonlinear heart rate dynamics in elderly inpatients. Relations with comorbidity and depression. Medicina 2010, 46, 393.
Blasco-Lafarga C, Martínez-Navarro I, Sisamón ME, Caus N, Yangüez E, Llorens-Soriano P. Linear and nonlinear heart rate dynamics in elderly inpatients. Relations with comorbidity and depression. Medicina. 2010; 46(6):393.Chicago/Turabian Style
Blasco-Lafarga, Cristina; Martínez-Navarro, Ignacio; Sisamón, María E.; Caus, Nuria; Yangüez, Emilio; Llorens-Soriano, Pere. 2010. "Linear and nonlinear heart rate dynamics in elderly inpatients. Relations with comorbidity and depression." Medicina 46, no. 6: 393.