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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation

1
Department of Anatomy, University of Tartu, Estonia
2
Department of Morphology, Estonian University of Life Sciences, Tartu
3
Department of Internal Medicine, University of Tartu, Estonia
4
Institute of Anthropology and Anatomy, Riga Stradins University, Latvia
*
Author to whom correspondence should be addressed.
Medicina 2010, 46(3), 204; https://doi.org/10.3390/medicina46030029
Received: 17 March 2009 / Accepted: 5 March 2010 / Published: 10 March 2010
Cell proliferation and apoptosis in the remnant rat kidney after treatment with lowdose irradiation was investigated.
Material and methods.
In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9).
Results
. Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation.
Conclusion
. The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.
Keywords: remnant kidney; rat; low-dose radiation; cell proliferation; apoptosis remnant kidney; rat; low-dose radiation; cell proliferation; apoptosis
MDPI and ACS Style

Aunapuu, M.; Arend, A.; Ots, M.; Pilmane, M. Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation. Medicina 2010, 46, 204.

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