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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Identification of predictors of inhospital postreperfusion mode of death in patients with acute ST-elevation myocardial infarction

1
Institute of Cardiology, Kaunas University of Medicine
2
Faculty of Informatics, Kaunas University of Technology
3
Faculty of Medicine, Kaunas University of Medicine, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2010, 46(2), 104; https://doi.org/10.3390/medicina46020015
Received: 2 September 2008 / Accepted: 5 February 2018 / Published: 10 February 2010
Objectives. The aim of this study was to identify the predictors of the postreperfusion mode of death using the distinctions in clinical characteristics of patients who died and survived after reperfusion therapy, treated due to ST-elevation myocardial infarction (STEMI).
Material and methods
. This consecutive study has involved 36 patients: 18 patients who died from progressive heart failure (PHF) (group 1, n=13) or from cardiac rupture (CR) (group 2, n=5) after primary coronary intervention. The control group consisted of 18 randomly selected patients who survived inhospital period (group 3). The initial and postreperfusion heart rate (HR), systolic and diastolic arterial pressures (SAP and DAP), maximal ST elevation (max ST­) and depression (max ST¯), ST score, TIMI flow grade, coronary score (CS), and their perireperfusion changes were assessed for each patient. The complex prognostic predictors – TIMI Risk Score and TIMI Risk Index – were also assessed. The data analysis was performed by standard statistical and machine learning approach methods.
Results
. The comparison of three patients’ groups according to simple ECG or circulatory characteristics showed that more significant differences were seen in postreperfusion characteristics or their perireperfusion changes. Herewith, the major part of significantly different characteristics (baseline SAP, DAP, and HR, postreperfusion SAP, DAP, ST score, and TIMI flow grade, resolution of ST score) was observed comparing both the groups of dead patients with survivors (control group). The differences in the complex predictors (TIMI Risk Score and TIMI Risk Index) were similar. However, the smallest number of significantly different characteristics was seen comparing both the groups of dead patients. The baseline DAP (P=0.045), postreperfusion SAP (P=0.04) and DAP (P=0.03), and ST score (P=0.0025) were higher in the patients who died from CR. The postreperfusion ST score and SAP were also identified as necessary components in the assessment of informative prognostic sets according to feature selection methods used in data mining field.
Conclusion
. The postreperfusion ST score, SAP, and DAP could be useful for the prediction of inhospital postreperfusion mode of death in patients with STEMI; evidently more clinical predictors could be useful for the prediction of general occurrence of postreperfusion deaths.
Keywords: percutaneous coronary interventions; myocardial reperfusion therapy; postreperfusion inhospital death; risk stratification of postreperfusion complications percutaneous coronary interventions; myocardial reperfusion therapy; postreperfusion inhospital death; risk stratification of postreperfusion complications
MDPI and ACS Style

Vaicekavičius, E.; Navickas, R.; Survila, L.; Štuikys, V.; Janavičius, A.; Valančius, K. Identification of predictors of inhospital postreperfusion mode of death in patients with acute ST-elevation myocardial infarction. Medicina 2010, 46, 104.

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