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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Cisplatin increases urinary sodium excretion in rats: gender-related differences

Institute of Oncology, Vilnius University
Department of Theoretical and Clinical Pharmacology, Kaunas University of Medicine
Department of Children’s Diseases, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2010, 46(1), 45;
Received: 10 November 2008 / Accepted: 4 January 2010 / Published: 9 January 2010
Objective. There are well-documented reports of cisplatin-associated hyponatremia in the literature, but there are no data on gender-dependent differences. The aim of the present study was to define characteristics of 24-hour urinary sodium excretion in young adult Wistar rats of both genders and to evaluate the gender-related effect of cisplatin.
Materials and methods. Twelve control Wistar rats (6 males and 6 females) and 12 cisplatintreated Wistar rats (6 males and 6 females) after a single and repeated injection of cisplatin (once a day for 3 days) at a dose of 2.5 mg/kg body weight into the caudal vein were examined. The experiment was carried out by measuring 24-h urinary sodium, potassium, chloride, magnesium, creatinine excretion and pH in the urine of age-matched male and female rats.
Results. The 24-h urinary sodium excretion, sodium/chloride ratio, and diuresis showed no gender-related differences in control rats. After a single administration of 2.5 mg/kg cisplatin, 24-h urinary sodium excretion was not significantly higher in cisplatin-treated rats than in gender-matched controls. After repeated cisplatin administration, 24-h urinary sodium excretion was significantly higher in cisplatin-treated male rats as compared to matched controls (P<0.05). No such effect was found in cisplatin-treated female rats.
Conclusion. The study data show that cisplatin enhances urinary sodium excretion in male but not in female rats. The mechanism of such a gender-related effect is not yet clear. Further investigations are necessary to elucidate the mechanism of this pharmacological effect of cisplatin.
Keywords: cisplatin; sodium urinary excretion; rats; gender-related differences cisplatin; sodium urinary excretion; rats; gender-related differences
MDPI and ACS Style

Stakišaitis, D.; Dudėnienė, G.; Jankūnas, R.J.; Graželienė, G.; Didžiapetrienė, J.; Pundzienė, B. Cisplatin increases urinary sodium excretion in rats: gender-related differences. Medicina 2010, 46, 45.

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