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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Cisplatin increases urinary sodium excretion in rats: gender-related differences

1
Institute of Oncology, Vilnius University
2
Department of Theoretical and Clinical Pharmacology, Kaunas University of Medicine
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Department of Children’s Diseases, Kaunas University of Medicine, Lithuania
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Author to whom correspondence should be addressed.
Medicina 2010, 46(1), 45; https://doi.org/10.3390/medicina46010008
Received: 10 November 2008 / Accepted: 4 January 2010 / Published: 9 January 2010
Objective. There are well-documented reports of cisplatin-associated hyponatremia in the literature, but there are no data on gender-dependent differences. The aim of the present study was to define characteristics of 24-hour urinary sodium excretion in young adult Wistar rats of both genders and to evaluate the gender-related effect of cisplatin.
Materials and methods. Twelve control Wistar rats (6 males and 6 females) and 12 cisplatintreated Wistar rats (6 males and 6 females) after a single and repeated injection of cisplatin (once a day for 3 days) at a dose of 2.5 mg/kg body weight into the caudal vein were examined. The experiment was carried out by measuring 24-h urinary sodium, potassium, chloride, magnesium, creatinine excretion and pH in the urine of age-matched male and female rats.
Results. The 24-h urinary sodium excretion, sodium/chloride ratio, and diuresis showed no gender-related differences in control rats. After a single administration of 2.5 mg/kg cisplatin, 24-h urinary sodium excretion was not significantly higher in cisplatin-treated rats than in gender-matched controls. After repeated cisplatin administration, 24-h urinary sodium excretion was significantly higher in cisplatin-treated male rats as compared to matched controls (P<0.05). No such effect was found in cisplatin-treated female rats.
Conclusion. The study data show that cisplatin enhances urinary sodium excretion in male but not in female rats. The mechanism of such a gender-related effect is not yet clear. Further investigations are necessary to elucidate the mechanism of this pharmacological effect of cisplatin.
Keywords: cisplatin; sodium urinary excretion; rats; gender-related differences cisplatin; sodium urinary excretion; rats; gender-related differences
MDPI and ACS Style

Stakišaitis, D.; Dudėnienė, G.; Jankūnas, R.J.; Graželienė, G.; Didžiapetrienė, J.; Pundzienė, B. Cisplatin increases urinary sodium excretion in rats: gender-related differences. Medicina 2010, 46, 45.

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