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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Evaluation of pituitary imaging in patients with PROP-1 gene mutation

1
Department of Endocrinology
2
Institute of Endocrinology
3
Department of Radiology,
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Author to whom correspondence should be addressed.
Medicina 2009, 45(9), 693; https://doi.org/10.3390/medicina45090090
Received: 20 May 2008 / Accepted: 4 September 2009 / Published: 9 September 2009
The most common genetically determined cause of multiple pituitary hormone deficiency is PROP-1 gene mutation. PROP-1 is a transcription factor involved in the development of pituitary gland and affects hormonal synthesis of anterior pituitary.
The aim of our study
was to evaluate radiological aspects of the pituitary region in patients with PROP-1 gene mutation. Pituitary imaging studies were performed in 12 patients with a confirmed PROP-1 gene mutation. Pituitary hyperplasia was found in 5 (42%) and pituitary hypoplasia in 4 (33%) patients. Changes in pituitary size were not associated with the type of PROP-1 gene mutation.
Keywords: hypopituitarism; combined pituitary hormone deficiency; growth hormone deficiency; PROP-1 mutation hypopituitarism; combined pituitary hormone deficiency; growth hormone deficiency; PROP-1 mutation
MDPI and ACS Style

Tkačenko, N.; Lašienė, D.; Jakštienė, S.; Basevičius, A.; Verkauskienė, R. Evaluation of pituitary imaging in patients with PROP-1 gene mutation. Medicina 2009, 45, 693.

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