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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Review on the effectiveness of prostate cancer brachytherapy

Department of Oncology
Department of Urology, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2009, 45(8), 660;
Received: 28 November 2007 / Accepted: 6 August 2009 / Published: 11 August 2009
Ultrasound-guided transperineal prostate brachytherapy is now widely used modality in the treatment of prostate cancer. The overall prostate-specific antigen (PSA) progression-free survival at 10 years is 80–90% for low-risk patients. The results of long-term follow-up have showed better biochemical diseasefree survival after I-125 and Pd-103 brachytherapy than after conventional external-beam radiotherapy and similar survival after radical prostatectomy. The most commonly reported dosimetric quantifiers include D90 (the dose that covers 90% of the prostate volume outlined on postimplant computed tomography images) and V100 (the fractional volume of the prostate that receives 100% of prescription dose). The biochemical diseasefree survival correlates with the dose. In low-risk patients, achieving a D90 dose of 140–160 Gy might be adequate for prostate-specific antigen control. However, high-risk disease might require a D90 dose higher than 200 Gy. In the immediate posttreatment period, the most common complication is acute urinary retention. Urinary symptoms such as frequency, nocturia, and dysuria occur commonly and are documented in about 80% of patients complaining of symptoms 2–3 months after treatment. Late urinary complications of brachytherapy include urethral stricture and incontinence. Incontinence is rare and mainly occurs in patients who had transurethral resection of the prostate either prior or after brachytherapy. Rectal complications (proctitis, rectal bleeding) are rare after prostate brachytherapy. Brachytherapy like external-beam radiotherapy but 50–85%, and most patients’ sexual quality and function are preserved. Since July 2007, the real-time I-125 prostate brachytherapy has been started in Lithuania and Baltic countries at the Hospital of Kaunas University of Medicine. A total of 150 low-risk patients (≤T2a, Gleason ≤6, PSA ≤10) were treated by this method. Permanent prostate brachytherapy is an appropriate method for standard treatment of localized prostate cancer.
Keywords: prostate cancer; brachytherapy; I-125 seeds prostate cancer; brachytherapy; I-125 seeds
MDPI and ACS Style

Inčiūra, A.; Jaruševičus, L.; Vaičiūnas, K.; Juozaitytė, E. Review on the effectiveness of prostate cancer brachytherapy. Medicina 2009, 45, 660.

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