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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Markers of endothelial dysfunction after cardiac surgery: Soluble forms of vascular-1 and intercellular-1 adhesion molecules

1
Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University
2
Center of Anesthesiology, Intensive Therapy, and Pain Management, Vilnius University Hospital Santariškių Klinikos
3
Department of Physiology, Biochemistry and Laboratory Medicine, Vilnius University, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2009, 45(6), 434; https://doi.org/10.3390/medicina45060056
Received: 15 July 2008 / Accepted: 3 June 2009 / Published: 8 June 2009
Endothelium forms an inner layer of vascular wall. It plays an important role in inflammatory process, regulation of vascular tone, and synthesis of thromboregulatory substances. Leukocyte and endothelium interactions during inflammation are regulated by different families of adhesion molecules. Increased levels of soluble forms of adhesion molecules have been detected in the circulating blood in conditions such as autoimmune diseases, transplant rejection, ischemia-reperfusion injury in addition to neutrophil- and endothelial membrane-bound forms reflecting the level of endothelial dysfunction. It is known that endothelial dysfunction is a risk factor for ischemic events such as stroke, myocardial infarction, unstable angina pectoris, ventricle fibrillation, necessity of revascularisation procedures, and death from cardiovascular reasons. Clinical studies showed that cardiac surgery has an impact on vascular endothelial function as well. The amount of endotheliumderived soluble forms of vascular-1 and intercellular-1 adhesion molecules increases after cardiopulmonary bypass suggesting endothelial dysfunction. However, further investigations are needed to be done to support the evidence that endothelial dysfunction proceeding heart surgery is one of the reasons of tissue ischemia-reperfusion injury.
Keywords: endothelial dysfunction; adhesion molecules; inflammation; cardiac surgery endothelial dysfunction; adhesion molecules; inflammation; cardiac surgery
MDPI and ACS Style

Balčiūnas, M.; Bagdonaitė, L.; Samalavičius, R.; Baublys, A. Markers of endothelial dysfunction after cardiac surgery: Soluble forms of vascular-1 and intercellular-1 adhesion molecules. Medicina 2009, 45, 434.

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