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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Methadone treatment and its dangers

Department of Intensive Care, Kaunas University of Medicine
Department of Intensive Care, Kaunas District Hospital
Department of Physiology, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2009, 45(5), 419;
Received: 1 October 2007 / Accepted: 5 May 2009 / Published: 10 May 2009
Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for μ-opioid receptors. Methadone has been used as a successful pharmacologic intervention for the treatment of heroin dependence and acute and chronic pain. This treatment is effective for opiate addiction, reducing morbidity and mortality associated with heroin use. However, overdosing with methadone has become a growing phenomenon because of the increased availability of this drug. Patients enrolled in a methadone maintenance treatment program may become physically dependent and may experience methadone withdrawal symptoms. In this review article, there are discussed about pharmacokinetic and pharmacodynamic properties of methadone, clinical symptoms of its overdose, dosage problems, detection of methadone in biological samples, treatment, and causes of methadone overdose-related deaths.
Keywords: methadone; opiates; overdose methadone; opiates; overdose
MDPI and ACS Style

Reingardienė, D.; Jodžiūnienė, L.; Lažauskas, R. Methadone treatment and its dangers. Medicina 2009, 45, 419.

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