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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Infusion solutions of gelatin derivates

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Department of Intensive Care, Kaunas University of Medicine
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Kaunas University of Medicine
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Department of Cardiac, Thoracic, and Vascular Surgery
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Department of Anesthesiology, Kaunas University of Medicine, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2009, 45(1), 77; https://doi.org/10.3390/medicina45010011
Received: 19 March 2008 / Accepted: 6 January 2009 / Published: 11 January 2009
Besides crystalloids, colloids are used for the treatment of hypovolemia and shock. They are high-molecular-weight proteins of bovine origin with properties of more rapid replacement of circulating blood volume. Iso-oncotic character provides the volume effect (»100%) close to the volume intravenously infused with the duration of action for 2–4 hours. Gelatin solutions are excreted with urine and feces in unchanged form without prolonged fixation in organism. Even in case of acute renal failure, gelatin peptides do not accumulate due to increased activity of proteolytic enzymes; therefore, they are the first-choice colloids. Gelatin solutions do not change coagulation as other colloids; just they may cause hemodilution as crystalloids do, so they are safe in case of hemorrhage and thrombocytopenia. There is a decreased risk of bleeding when gelatin solutions are used in surgery as compared with other colloids; in addition, they protect from hypotension due to vasodilatation in epidural or spinal analgesia. Gelatin solutions may cause compensatory hyperemia and increase of cardiac output, cardiac index, myocardial contractility, mean arterial blood pressure, and diuresis; in addition, oxygen delivery to the tissues improves. The dosage depends on clinical condition of a patient, and it is suggested to be 100–2000 mL and even more, for isovolemic hemodilution – 20 mL/kg of body weight. Adverse reactions such as anaphylactoid or anaphylactic to gelatin derivates are rare and similar to other colloids.
Keywords: colloids; gelatin derivates; indications colloids; gelatin derivates; indications
MDPI and ACS Style

Adukauskienė, D.; Mažeikienė, S.; Veikutienė, A.; Rimaitis, K. Infusion solutions of gelatin derivates. Medicina 2009, 45, 77.

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