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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Evaluation of needs for therapeutic monitoring of digoxin in a tertiary hospital

Department of Theoretical and Clinical Pharmacology
Department of Nephrology, Kaunas University of Medicine
Hospital Pharmacy, Kaunas University of Medicine Hospital
Institute of Cardiology, Kaunas University of Medicine
Laboratory of Clinical Chemistry and Hematology, Kaunas University of Medicine Hospital, Lithuania
Author to whom correspondence should be addressed.
Medicina 2009, 45(1), 46;
Received: 16 June 2008 / Accepted: 6 January 2009 / Published: 11 January 2009
Objectives. To collect the data about the consumption of digoxin, evaluate the tendencies towards usage of this drug during 2004–2007, and to find departments, which cover the main part of digoxin consumption in a tertiary hospital. To evaluate the intensity of serum digoxin concentration measurements during 2005–2007.
Material and methods
. Our study was carried out in a tertiary hospital with 2600 beds and 63 departments. Consumption of digoxin is expressed in defined daily doses per 100 occupied beds daily during 2004–2007. All serum concentration measurements in 2005–2007 were evaluated.
Results. The main consumers of digoxin in 2007 were the Units of Endocrinology, Pulmonology and Immunology, Cardiology II, Neurosurgical Reanimation and Intensive Care, Neurology, Eye Disorders I, Intensive Care Unit of Cardiology; they consumed 51.05% of total digoxin. In total, 58 digoxin measurements were performed in 2005, 89 in 2006, and 64 in 2007. The intensity of serum concentration measurements for digoxin is 1/147 (one measurement for 147 defined daily doses) in 2005, 1/89 in 2006, and 1/107 in 2007. These results show that intensity of serum digoxin concentration measurements is low.
Conclusions. Twenty-two out of the 63 departments cover 90% of digoxin consumption per year. The changes in digoxin consumption were not statistically significantly different in 2004– 2007. There was a tendency towards an increase in serum digoxin concentration measurements during the 3-year period. Digoxin concentration outside therapeutic ranges was established in about half of all cases in 2005–2006, but there was an increase in normal serum concentration in 2007.
Keywords: rationality; defined daily dose; therapeutic drug monitoring; digoxin rationality; defined daily dose; therapeutic drug monitoring; digoxin
MDPI and ACS Style

Penkauskaitė, J.; Mačiulaitis, R.; Varanavičienė, B.; Milvidaitė, I.; Tarutienė, B. Evaluation of needs for therapeutic monitoring of digoxin in a tertiary hospital. Medicina 2009, 45, 46.

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