Next Article in Journal
Free radical-scavenging activities of Crataegus monogyna extracts
Previous Article in Journal
The center of the human porta hepatis
Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Effect of Perilla frutescens aqueous extract on free radical production by human neutrophil leukocytes

1
Department of Dental and Maxillofacial Orthopedics
2
Department of Dental and Oral Disorders
3
Department of Physiology, Kaunas University of Medicine, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2008, 44(9), 699; https://doi.org/10.3390/medicina44090090
Received: 3 December 2007 / Accepted: 10 September 2008 / Published: 15 September 2008
Objective. The present study was intended to evaluate the antioxidant properties of aqueous extract of the Perilla frutescens (L.) Britton.
Material and methods. The antioxidant properties of Perilla frutescens were analyzed employing neutrophil leukocytes stimulated by the nonopsonized Escherichia coli. The neutrophil leukocytes were affected by adding an aqueous extract of Perilla. The generation of the reactive oxygen species by neutrophil leukocytes was investigated using assessment of luminol- and lucigenin-dependent chemiluminescence.
Results. We found out that the treatment of neutrophil leukocytes with the Perilla aqueous extract inhibited the release of reactive oxygen species, measured as luminol- and lucigenindependent chemiluminescence, by about 30% and more than 90%, respectively.
Conclusion
. The results of this study show that the aqueous extract of the Perilla frutescens inhibits significantly free radical production by neutrophil leukocytes, which was especially obvious when the lucigenin-dependent chemiluminescence assessment method was applied.
Keywords: Perilla frutescens; antioxidant; lucigenin; luminol; chemiluminescence Perilla frutescens; antioxidant; lucigenin; luminol; chemiluminescence
MDPI and ACS Style

Žekonis, G.; Žekonis, J.; Šadzevičienė, R.; Šimonienė, G.; Kėvelaitis, E. Effect of Perilla frutescens aqueous extract on free radical production by human neutrophil leukocytes. Medicina 2008, 44, 699.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop