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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Metastatic amelanotic nodular melanoma during pregnancy

Department of Skin and Venereal Diseases
Department of Pathological Anatomy
Department of Oncology, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2008, 44(6), 467;
Received: 14 January 2008 / Accepted: 11 June 2008 / Published: 16 June 2008
This case report presents a very aggressive course of amelanotic nodular melanoma during pregnancy resulting in death five months after delivery. A 34 year-old Caucasian woman at 19th week of the second pregnancy was diagnosed having amelanotic nodular melanoma (tumor thickness – 2.5 mm) with metastases to the regional right inguinal lymph node. Amelanotic nodular melanoma represents malignant melanocytic tumor of the skin, which clinically mimics a variety of benign and malignant skin conditions and therefore commonly leads to delayed diagnosis. Though primary tumor was excised immediately, other treatment procedures as radical lymphadenectomy and chemotherapy were delayed, and immunotherapy was not given totally. At the 29th week of pregnancy, the woman via naturalem delivered a healthy female child, and the chemotherapy was started. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our reported case. Such patients seems to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.
Keywords: amelanotic melanoma; metastatic melanoma; pregnancy; therapy amelanotic melanoma; metastatic melanoma; pregnancy; therapy
MDPI and ACS Style

Jasaitienė, D.; Valiukevičienė, S.; Makštienė, J.; Juodžbalienė, E.B. Metastatic amelanotic nodular melanoma during pregnancy. Medicina 2008, 44, 467.

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