Expression of matrix metalloproteinases (MMP-2 and MMP-9) in vocal fold polyps
Material and methods. The immunohistochemical expression of MMP-2 and MMP-9 was investigated in specimens taken by endolaryngeal microsurgery from vocal fold polyps (n=30) and normal tissue of vocal fold (n=13, control group). Expression of MMP-2 and MMP-9, both in epithelium and stroma cells, was graded on a semiquantitative scale, ranging from 0 (no expression) to 6 points (high expression).
Results. A statistically significant increase was observed in the expression of MMP-2 in stroma cells (P=0.0176) of vocal fold polyps compared to control vocal fold group, whereas no significant difference in the expression of MMP-2 was found in epithelium cells (P=0.1487). Comparison of expression of MMP-2 and MMP-9 in epithelium cells revealed a statistically significant increase in MMP-9 expression (P<0.01) in both groups. However, there was no statistically significant difference in the expression of MMP-9 between groups of vocal fold polyps and control vocal folds.
Conclusion. Expression of MMP-2 in stroma was significantly higher in polyps than in normal tissue of vocal folds. Our data draw attention to the role of MMP-2 in the development of vocal fold polyps and necessity of further investigations to define its function in morphogenesis of laryngeal benign, premalignant, and malignant lesions.
Lesauskaitė, V.; Uloza, V.; Liutkevičius, V.; Pangonytė, D. Expression of matrix metalloproteinases (MMP-2 and MMP-9) in vocal fold polyps. Medicina 2008, 44, 322.
Lesauskaitė V, Uloza V, Liutkevičius V, Pangonytė D. Expression of matrix metalloproteinases (MMP-2 and MMP-9) in vocal fold polyps. Medicina. 2008; 44(4):322.Chicago/Turabian Style
Lesauskaitė, Vaiva; Uloza, Virgilijus; Liutkevičius, Vykintas; Pangonytė, Dalia. 2008. "Expression of matrix metalloproteinases (MMP-2 and MMP-9) in vocal fold polyps." Medicina 44, no. 4: 322.