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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Effect of smoking on neutrophil oxidative metabolism

Department of Prosthodontics, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2008, 44(3), 195;
Received: 8 September 2005 / Accepted: 26 November 2007 / Published: 1 December 2007
Alterations in neutrophil function by tobacco products may play a central role in the pathogenesis of periodontal diseases and several smoking-related systemic diseases. The aim of the study was to evaluate the effect of smoking on neutrophil oxidative metabolism.
Materials and methods. The study included 17 smoking men free of systemic diseases who were referred for treatment of various odontological diseases to outpatient department of Kaunas University of Medicine Hospital. The age of subjects varied from 22 to 43 years. All subjects answered the questions about smoking habits. Clinical examination included assessment of oral hygiene status according to the OHI-s index and periodontal status according to Russell and Ramfjord indices. To evaluate the oxidative metabolism of neutrophils, luminol- and liucigenin-dependent chemiluminescence and nitroblue tetrazolium test were used.
. After smoking, extracellular liucigenin-dependent chemiluminescence response was higher as compared to the response before smoking, but total (intra- and extracellular) luminol-dependent chemiluminescence response was the same both before and after smoking. Exposure of neutrophils to smoking caused a significant increase in nitroblue tetrazolium reduction.
Conclusion. The release of reactive oxygen species in neutrophils exposed to smoking may alter the pathogenic processes in periodontal diseases.
Keywords: neutrophils; smoking; reactive oxygen species; chemiluminescence; nitroblue tetrazolium reduction test neutrophils; smoking; reactive oxygen species; chemiluminescence; nitroblue tetrazolium reduction test
MDPI and ACS Style

Zasimauskas, D.; Žekonis, G. Effect of smoking on neutrophil oxidative metabolism. Medicina 2008, 44, 195.

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