Effect of smoking on neutrophil oxidative metabolism
Materials and methods. The study included 17 smoking men free of systemic diseases who were referred for treatment of various odontological diseases to outpatient department of Kaunas University of Medicine Hospital. The age of subjects varied from 22 to 43 years. All subjects answered the questions about smoking habits. Clinical examination included assessment of oral hygiene status according to the OHI-s index and periodontal status according to Russell and Ramfjord indices. To evaluate the oxidative metabolism of neutrophils, luminol- and liucigenin-dependent chemiluminescence and nitroblue tetrazolium test were used.
Results. After smoking, extracellular liucigenin-dependent chemiluminescence response was higher as compared to the response before smoking, but total (intra- and extracellular) luminol-dependent chemiluminescence response was the same both before and after smoking. Exposure of neutrophils to smoking caused a significant increase in nitroblue tetrazolium reduction.
Conclusion. The release of reactive oxygen species in neutrophils exposed to smoking may alter the pathogenic processes in periodontal diseases.
Zasimauskas, D.; Žekonis, G. Effect of smoking on neutrophil oxidative metabolism. Medicina 2008, 44, 195.
Zasimauskas D, Žekonis G. Effect of smoking on neutrophil oxidative metabolism. Medicina. 2008; 44(3):195.Chicago/Turabian Style
Zasimauskas, Darius; Žekonis, Gediminas. 2008. "Effect of smoking on neutrophil oxidative metabolism." Medicina 44, no. 3: 195.