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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Vasopressin for treatment of hemodynamic disorders

Clinic of Intensive Therapy
Laboratory of Intensive Therapy and Investigations of Hemodynamics, Institute for Biomedical Research
Department of Physiology, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2008, 44(2), 167;
Received: 4 June 2007 / Accepted: 8 February 2008 / Published: 13 February 2008
Vasopressin is a 9-amino acid peptide synthesized by magnocellular neurons of the hypothalamus and released from posterior pituitary gland. The primary physiological role of vasopressin is the maintenance of fluid homeostasis. In this review, the classification of vasopressin receptors, namely V1 vascular, V2 renal, V3 pituitary, oxytocin receptors, and purinergic receptors, and the effects of vasopressin on vascular smooth muscles, the heart, and the kidneys are discussed. Mortality rates of vasodilatory (or distributive), for example septic shock, are high. The use of vasopressin is an alternative therapy for vasodilatory shock with better outcome. Vasopressin is effective in resuscitation of adults after ventricular fibrillation or pulseless tachycardia, when epinephrine is not effective.
Keywords: vasopressin; vasopressin receptors; vasodilatory shock; septic shock; resuscitation vasopressin; vasopressin receptors; vasodilatory shock; septic shock; resuscitation
MDPI and ACS Style

Adukauskienë, D.; Ðirvinskas, E.; Këvelaitis, E. Vasopressin for treatment of hemodynamic disorders. Medicina 2008, 44, 167.

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