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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Variability of phenolic compounds in flowers of Achillea millefolium wild populations in Lithuania

Department of Pharmaceutical Chemistry and Pharmacognosy
Laboratory of Economic Botany, Institute of Botany, Kaunas University of Medicine, Lithuania
Author to whom correspondence should be addressed.
Medicina 2008, 44(10), 775;
Received: 13 January 2008 / Accepted: 8 October 2008 / Published: 13 October 2008
Achillea millefolium L. sensu lato (yarrow) is the best-known species of the genus Achillea due to numerous medicinal applications both in folk and conventional medicine. Phenolic compounds such as flavonoids and phenol carbonic acids are present in yarrow and constitute one of the most important groups of pharmacologically active substances. In the present study, yarrow flowers gathered from native populations in different locations of Lithuania were analyzed for phenolic compound composition. High-performance liquid chromatography (HPLC) was used for chemical analyses. Eight phenolic compounds – chlorogenic acid and flavonoids, namely vicenin-2, luteolin-3',7-di-O-glucoside, luteolin-7-O-glucoside, rutin, apigenin-7-O-glucoside, luteolin, and apigenin – were identified in the extracts from yarrow flowers. Considerable variation in accumulation of phenolic compounds among the flowers from different locations was observed. The samples were divided into two main groups based on chemical composition: the first group was characterized by lower than the mean total amount of the identified phenolics; the second was formed from samples accumulating higher concentrations of investigated secondary metabolites. The total amount of the identified phenolics in yarrow flowers from different populations varied from 13.290 to 27.947 mg/g.
Keywords: Achillea millefolium; phenolic compounds; flavonoids; flowers Achillea millefolium; phenolic compounds; flavonoids; flowers
MDPI and ACS Style

Benetis, R.; Radušienė, J.; Janulis, V. Variability of phenolic compounds in flowers of Achillea millefolium wild populations in Lithuania. Medicina 2008, 44, 775.

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