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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Natural clearance of hepatitis C virus in hemophilia patients

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Department of Traditional Infectology, Tuberculosis and AIDS
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Department of Internal Diseases
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Institute of Immunology, Riga Stradins University
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University Children’s Hospital, Latvia
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Department of Pediatrics, Riga Stradins University, Latvia
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Author to whom correspondence should be addressed.
Medicina 2008, 44(1), 15; https://doi.org/10.3390/medicina44010003
Received: 18 April 2007 / Accepted: 21 June 2007 / Published: 26 June 2007
Objective. The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes.
Material and methods. From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophilia patients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method.
Results. HCV infection is common among hemophilia patients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively; OR=3.50; P<0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophilia patients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele – 4 (11.11%) and 9 (1.67%); OR=7.38; P<0.05).
Conclusions
. Natural clearance of HCV infection is frequently found in hemophilia patients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophilia patients.
Keywords: hepatitis C virus; hemophilia; natural clearance; human leukocyte antigen hepatitis C virus; hemophilia; natural clearance; human leukocyte antigen
MDPI and ACS Style

Simanis, R.; Lejniece, S.; Sochnevs, A.; Eglite, J.; Chernevska, G.; Kovalova, Z.; Gardovska, D.; Jeruma, A.; Kuse, V.; Viksna, L. Natural clearance of hepatitis C virus in hemophilia patients. Medicina 2008, 44, 15.

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