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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Brain natriuretic peptide and other cardiac markers predicting left ventricular remodeling and function two years after myocardial infarction

1
Institute of Cardiology
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Department of Cardiology, Kaunas University of Medicine, Lithuania
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Author to whom correspondence should be addressed.
Medicina 2007, 43(9), 708; https://doi.org/10.3390/medicina43090092
Received: 23 January 2007 / Accepted: 3 September 2007 / Published: 8 September 2007
Background. Left ventricular remodeling is a complex pathologic process of progressive left ventricular dilatation, leading to dysfunction and heart failure in patients after myocardial infarction.
Objective
. To evaluate biochemical markers, reflecting cardiac remodeling process after first myocardial infarction and compare those markers with clinical characteristics of left ventricular remodeling.
Material and methods
. Brain natriuretic peptide, troponin I, creatine kinase, creatine kinase MB mass, lactate dehydrogenase levels were measured in 30 patients with acute myocardial infarction on days 1, 2, 3–7 . Brain natriuretic peptide was measured at 3 months, 6 months, and 2 years after myocardial infarction. Echocardiographic parameters of left ventricular remodeling were determined in acute phase (day 1–3), at 3 months, 6 months, and 2 years after MI.
Results
. In acute phase, brain natriuretic peptide level progressively increased according to worsening of left ventricular geometry: in normal left ventricle geometry group, brain natriuretic peptide level was 84.1 (58.7–121) pg/mL, in concentric remodeling group – 125 (69.2–165) pg/mL, in concentric hypertrophy group – 128 (74–368) pg/mL, and in eccentric hypertrophy group – 470 (459–494) pg/mL, P=0.02. Patients who had increased left ventricular end diastolic diameter index during 2-year period had higher brain natriuretic peptide level in the acute phase (584 (249–865) pg/mL vs. 120 (67–202) pg/mL, P=0.04) and also higher peak lactate dehydrogenase and troponin I levels.
Conclusions
. Brain natriuretic peptide level in acute phase of myocardial infarction is strongly associated with the markers of myocardial injury and related to left ventricular geometry changes and remodeling. Brain natriuretic peptide together with troponin I levels in acute phase of myocardial infarction might be useful in predicting subsequent cardiac function.
Keywords: brain natriuretic peptide; cardiac markers; left ventricular remodeling; myocardial infarction brain natriuretic peptide; cardiac markers; left ventricular remodeling; myocardial infarction
MDPI and ACS Style

Grybauskienė, R.; Karčiauskaitė, D.; Braždžionytė, J.; Janėnaitė, J.; Bertašienė, Z.; Grybauskas, P. Brain natriuretic peptide and other cardiac markers predicting left ventricular remodeling and function two years after myocardial infarction. Medicina 2007, 43, 708.

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