Next Article in Journal
Health-related quality-of-life assessment in patients with low back pain using SF-36 questionnaire
Previous Article in Journal
Acute and transient psychotic disorders in a rapidly developing country, State of Qatar
Article Menu

Article Versions

Export Article

Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Effects of ß-glucans on the immune system

1
Department of Physiology, Kaunas University of Medicine
2
Institute of Oncology, Vilnius University, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2007, 43(8), 597; https://doi.org/10.3390/medicina43080076
Received: 16 January 2007 / Accepted: 6 August 2007 / Published: 11 August 2007
PDF [218 KB, uploaded 5 July 2018]

Abstract

ß-Glucans are naturally occurring polysaccharides. These glucose polymers are constituents of the cell wall of certain pathogenic bacteria and fungi. The healing and immunostimulating properties of mushrooms have been known for thousands of years in the Eastern countries. These mushrooms contain biologically active polysaccharides that mostly belong to group of ß-glucans. These substances increase host immune defense by activating complement system, enhancing macrophages and natural killer cell function. The induction of cellular responses by mushroom and other ß-glucans is likely to involve their specific interaction with several cell surface receptors, as complement receptor 3 (CR3; CD11b/CD18), lactosylceramide, selected scavenger receptors, and dectin-1 (ßGR). ß-Glucans also show anticarcinogenic activity. They can prevent oncogenesis due to the protective effect against potent genotoxic carcinogens. As immunostimulating agent, which acts through the activation of macrophages and NK cell cytotoxicity, ß-glucan can inhibit tumor growth in promotion stage too. Antiangiogenesis can be one of the pathways through which ß-glucans can reduce tumor proliferation, prevent tumor metastasis. ß-Glucan as adjuvant to cancer chemotherapy and radiotherapy demonstrated the positive role in the restoration of hematopiesis following by bone marrow injury. Immunotherapy using monoclonal antibodies is a novel strategy of cancer treatment. These antibodies activate complement system and opsonize tumor cells with iC3b fragment. In contrast to microorganisms, tumor cells, as well as other host cells, lack ß-glucan as a surface component and cannot trigger complement receptor 3-dependent cellular cytotoxicity and initiate tumor-killing activity. This mechanism could be induced in the presence of ß-glucans.
Keywords: ß-glucan; anticarcinogenic activity; monoclonal antibodies; complement receptor ß-glucan; anticarcinogenic activity; monoclonal antibodies; complement receptor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Akramienė, D.; Kondrotas, A.; Didžiapetrienė, J.; Kėvelaitis, E. Effects of ß-glucans on the immune system. Medicina 2007, 43, 597.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Medicina EISSN 1010-660X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top