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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The importance of T-lymphocyte subsets on overall survival of colorectal and gastric cancer patients

1
Laboratory of Experimental Oncology
2
Department of Abdominal Surgery, Institute of Oncology, Vilnius University, Lithuania
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Author to whom correspondence should be addressed.
Medicina 2007, 43(7), 548; https://doi.org/10.3390/medicina43070069
Received: 29 June 2006 / Accepted: 18 May 2007 / Published: 23 May 2007
The aim of this study was to evaluate the influence of cellular immunity parameters on overall survival of colorectal and gastric cancer patients after surgery. The parameters of cellular immunity (CD3+, CD4+, CD8+, CD20+, and CD16+) were determined by immunofluorescence method. Cox regression analysis showed no impact of the estimated preoperative and postoperative parameters of cellular immunity on overall survival of colorectal cancer patients and similarly of gastric cancer patients in stage II. However, the analysis showed that the survival of colorectal and gastric cancer patients in stage III depended on immunological parameters determined before surgery: CD3+ (P=0.007 and P=0.007, respectively), CD4+ (P=0.021 and P=0.011, respectively), and CD8+ (P=0.047 and P=0.007) counts. Only the survival of colorectal cancer patients depended on natural killer cell number (P=0.009). Kaplan-Meier analysis showed that patients with stage III colorectal and gastric cancer had better survival rates when absolute number of CD3+ lymphocytes, determined before surgery, was greater than 0.8×109/L, CD4+ – greater than 0.25×109/L, CD8+ – greater than 0.3×109/L. Colorectal cancer patient survived longer when the number of natural killer cells CD16+ was more than 0.25×109/L. This study suggests that higher levels of the absolute number of lymphocyte subsets before surgery have a beneficial effect on overall survival of gastric and colorectal cancer patients in stage III.
Keywords: gastric cancer; colorectal cancer; lymphocyte subsets; immune system gastric cancer; colorectal cancer; lymphocyte subsets; immune system
MDPI and ACS Style

Milašienė, V.; Stratilatovas, E.; Norkienė, V. The importance of T-lymphocyte subsets on overall survival of colorectal and gastric cancer patients. Medicina 2007, 43, 548.

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