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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Research for practice: a new in vitro test for identification of tuberculosis infection

Department of Pediatric Diseases
Department of Pulmonology and Immunology
Institute for Biomedical Research, Kaunas University of Medicine, Lithuania
Oxford Immunotec, United Kingdom
Author to whom correspondence should be addressed.
Medicina 2007, 43(7), 519;
Received: 20 November 2006 / Accepted: 29 June 2007 / Published: 4 July 2007
Tuberculosis is one of the biggest global health problems. One-third of the world’s population (2 billion) is latently infected with tuberculosis. The tuberculin skin test is commonly used to diagnose tuberculosis infection. This test has poor specificity and sensitivity, cross-reactivity with bacille Calmette-Guérin vaccination and many environmental mycobacteria, and poor sensitivity (only 75–90% in active tuberculosis). Mycobacterium tuberculosis activates a strong T cell-mediated immune response. That is why, a better marker for tuberculosis infection could be the presence of mycobacteria specific interferon-y-secreting T cells. These cells can be identified in blood or any other sample, which contains T cells. The test specificity is 99.9% (in low-risk control groups), and the sensitivity is 97.2% (in subjects with culture-confirmed active disease). New in vitro diagnostic test of tuberculosis, based on tuberculosis-induced immunological mechanisms, seems to be more specific and useful as previous methods.
Keywords: tuberculosis; tuberculin skin test; interferon-gamma; ELISPOT; T-SPOT TB tuberculosis; tuberculin skin test; interferon-gamma; ELISPOT; T-SPOT TB
MDPI and ACS Style

Hansted, E.; Šitkauskienė, B.; Kėvalas, R.; Tattersall, A.; Day, T. Research for practice: a new in vitro test for identification of tuberculosis infection. Medicina 2007, 43, 519.

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