The association between cytomegalovirus infection and aging process
Materials and methods. In accordance with special criteria of the assessment of biological age, 146 healthy elderly women aged 60–90 years were divided into three groups: Group 1 – slow aging group (37 women, 25.4%); Group 2 – physiological aging group (58 women, 39.7%); Group 3 – premature aging group (51 women, 34.9%). Immune response to cytomegalovirus was studied using methods of enzyme immunoassay and indirect immunofluorescence.
Results. Comparing immune response to cytomegalovirus in different aging groups, highest titres of both IgG antibodies against early antigens and IgA antibodies against late structural antigens were found in premature aging group. Results showed that premature aging was associated with an increased level of IgA antibodies characteristic for cytomegalovirus symptomatic infection and its frequent reactivations.
Conclusion. Cytomegalovirus infection is associated with an increased risk of premature aging (OR=9.8; P<0.01).
Kanapeckienė, V.; Kalibatas, J.; Redaitienė, E.; Čeremnych, J. The association between cytomegalovirus infection and aging process. Medicina 2007, 43, 419.
Kanapeckienė V, Kalibatas J, Redaitienė E, Čeremnych J. The association between cytomegalovirus infection and aging process. Medicina. 2007; 43(5):419.Chicago/Turabian Style
Kanapeckienė, Virginija; Kalibatas, Julius; Redaitienė, Elvyra; Čeremnych, Jelena. 2007. "The association between cytomegalovirus infection and aging process." Medicina 43, no. 5: 419.