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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Study of apoptosis in normal skin tissues

Vilnius University, Lithuania
Author to whom correspondence should be addressed.
Medicina 2007, 43(4), 301;
Received: 18 May 2006 / Accepted: 16 January 2007 / Published: 21 January 2007
The aim of the study was to investigate the apoptosis in normal human skin by examination of all epidermal layers.
Material and methods
. The normal skin epidermis of 15 healthy subjects was investigated by TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP-X nick end labeling) technique. Apoptotic cells were evaluated in the germinative and differential compartments and stratum corneum. Only highly TUNEL-positive cells with typical morphological DNA fragmentation signs were calculated.
. In vital strata (except stratum corneum) of normal skin epidermis, 37.5% of all TUNEL-positive cells were observed in the germinative compartment and 41.7% in the granular layer of differential compartment.
. The study showed that apoptosis occurs in all layers of normal skin epidermis. It demonstrates that apoptosis is highly important in the renewal of cells and formation of epidermal structure within all compartments.
Keywords: apoptosis; differentiation; keratinocytes; TUNEL apoptosis; differentiation; keratinocytes; TUNEL
MDPI and ACS Style

Grigaitienė, J.; Marčiukaitienė, I.; Blažienė, A.; Chomičienė, A. Study of apoptosis in normal skin tissues. Medicina 2007, 43, 301.

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