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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The diuretic effect of cornflower water extract

1
Department of Drugs Technology and Social Pharmacy, Kaunas University of Medicine, Lithuania
2
Brno University of Veterinary and Pharmaceutical Sciences, Czech Republic
3
Department of Physiology, Kaunas University of Medicine, Lithuania
*
Author to whom correspondence should be addressed.
Medicina 2007, 43(3), 221; https://doi.org/10.3390/medicina43030027
Received: 21 November 2006 / Accepted: 12 February 2007 / Published: 17 February 2007
The objective of this study was to evaluate and compare the effect of cornflower water extract and hydrochlorothiazide on diuresis, Na+ and K+ excretion, and the changes in the prostaglandin E2 and kinins levels in the blood plasma.
Material and methods. Male Wistar rats were used in all experiments. Animals were divided into nine groups. Diuretic activity was investigated according to the technique proposed by E. B. Berchin; urinary electrolyte contents were analyzed by flame photometry. Prostaglandin E2 content was measured by radioimmunoassay using 3H isotopes, kinins – by enzymatic methods.
Results
. It has been established that in male rats, receiving hydrochlorothiazide, the volume of urine excreted two and four hours after the administration of the drug was by 18% and 17%, respectively, higher as compared to the rats that were given cornflower water extract (P<0.05). The diuretic effect of cornflower water extract was noted in the animal group receiving this extract as compared to the control group: after two hours, the volume of urine excreted increased from 2.03±0.03 mL to 2.44±0.04 mL and after four hours – from 3.88±0.07 mL to 5.35±0.1 mL. Administration of hydrochlorothiazide under the load of salts and water resulted in a higher excretion of sodium and potassium as compared to the effect of cornflower water extract. The highest prostaglandin levels were found in the blood plasma of the animals receiving hydrochlorothiazide. Under the load of salts and water, a 13% and 15% increase, respectively, in the amount of prostaglandins was observed in the animals that were given cornflower water extract compared to the control animals (P<0.05). The greatest increase in the amount of kinins was found in the groups of animals that were given hydrochlorothiazide under the load of salts and water (14% and 22%, respectively). Kinin levels did not differ statistically significantly between the control group and the groups receiving cornflower water extract.
Conclusion. Cornflower water extract possesses diuretic activity, but its effect was lower than that of hydrochlorothiazide.
Keywords: diuresis; sodium ions; potassium ions; kinins; prostaglandins diuresis; sodium ions; potassium ions; kinins; prostaglandins
MDPI and ACS Style

Klimas, R.; Rabišková, M.; Civinskienė, G.; Bernatonienė, J. The diuretic effect of cornflower water extract. Medicina 2007, 43, 221.

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