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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
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Ischemic heart disease: structural changes of the atria in preinfarction and postinfarction stages

Laboratory of Cardiac Pathology, Institute of Cardiology, Kaunas University of Medicine, Lithuania
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Medicina 2007, 43(2), 125; https://doi.org/10.3390/medicina43020015
Received: 6 November 2006 / Accepted: 29 January 2007 / Published: 3 February 2007
Objective. The aim of this study was to determine atrial structural remodeling during the development of ischemic heart disease.
Material and methods. Quantitative histomorphometric parameters of interstitial collagen network (the percentage volume, perimeter, number of fibers per field and collagen–cardiomyocyte volume ratio) of the atria of 132 autopsied men (mean age 49.7±8.9 years) who had died suddenly (within 6 hours since the onset of terminal heart attack symptoms) due to the first (no postinfarction scars) and repeated (postinfarction scars present) acute “pure” ischemic heart disease were investigated.
Results
. The main remodeling feature of the wall of the both atria among ischemic heart disease subjects is hypertrophy of cardiomyocytes and hyperplasia of interstitial fibrillar collagen network with the maintenance of the same proportion of contractile myocardium and fibrillar collagen network volume. This proportion in the case of the left atrium persists in both pre- and postinfarction ischemic heart disease groups, while myocardium of the right atrium in preinfarction group subjects is characterized by an excess increase of collagen network as compared to cardiomyocyte hypertrophy, which levels again with that of the control in postinfarction group.
Conclusions
. At preinfarction stage of ischemic heart disease, remodeling of both atria develops and progresses in the left atrium at postinfarction stage in the relationship with increase of left ventricular dysfunction.
Keywords: ischemic heart disease; left and right atria; left ventricular dysfunction; remodeling ischemic heart disease; left and right atria; left ventricular dysfunction; remodeling
MDPI and ACS Style

Pangonytė, D.; Morkūnaitė, K.; Stalioraitytė, E.; Zaikauskienė, J. Ischemic heart disease: structural changes of the atria in preinfarction and postinfarction stages. Medicina 2007, 43, 125.

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