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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Collagen network changes in basilar artery in aging

1
Department of Histology and Embryology
2
Department of Pathological Anatomy, Kaunas University of Medicine, Lithuania
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Author to whom correspondence should be addressed.
Medicina 2007, 43(12), 964; https://doi.org/10.3390/medicina43120126
Received: 1 March 2007 / Accepted: 16 November 2007 / Published: 21 November 2007
Objective. The aim of this study was to examine and evaluate morphometrically age-related changes in collagen network in the tunica media of human basilar artery.
Materials and methods
. Histological analysis of the basilar arteries obtained from 89 individuals, aged 20 to 85 years, was performed. The study has been carried out by standard histological technique; histological samples were stained with picrosirius red. Detailed quantitative analysis of collagen bundle network in the tunica media of basilar artery was performed.
Results. We analyzed collagen network area, perimeter and number of collagen bundles in the tunica media of the basilar artery. After investigation of age-related changes in collagen network area in men and women, we determined that in both genders collagen network area in the tunica media of the basilar artery increased with age. Analyzing the perimeter and number of collagen bundles in both genders by different age groups, it was found that they decreased with age. We found a statistically significant correlation between all the measured parameters and the age.
Conclusions. The area of collagen bundles increased, the number and perimeter of collagen bundles decreased with age in both genders in the tunica media of human basilar artery. While aging, the structure of collagen bundle network became less branchy, collagen fibers merged, their cross section area enlarged.
Keywords: basilar artery; collagen fibers; aging basilar artery; collagen fibers; aging
MDPI and ACS Style

Gudienė, D.; Valančiūtė, A.; Vėlavičius, J. Collagen network changes in basilar artery in aging. Medicina 2007, 43, 964.

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