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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

The role of D-dimer in the diagnosis of strangulated small-bowel obstruction

Department of Surgery, Kaunas University of Medicine, Lithuania
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Medicina 2007, 43(11), 850; https://doi.org/10.3390/medicina43110109
Received: 20 November 2006 / Accepted: 12 November 2007 / Published: 17 November 2007
Background. Various diagnostic utilities have been used in the diagnosis of strangulated obstruction. Despite this, there is no simple and reliable marker for it, and diagnosis in most cases is based on clinical, laboratory, and radiological investigations. The purpose of the present study was to assess D-dimer value in the diagnosis of strangulated obstruction.
Methods
. A prospective study of 53 patients with small-bowel obstruction was conducted. Strangulated obstruction was present in 15 (28.3%) patients. Eight (53%) had intestinal necrosis, while 7 (47%) reversible ischemia. The blood samples were taken and analyzed with NycoCard Reader method with monoclonal antibodies specific for D-dimer neoantigens.
Results
. In the presence of intestinal necrosis, there was a higher D-dimer level found than in the cases with reversible ischemia or simple small-bowel obstruction, although this difference did not reach statistically significant level. The D-dimer test had a sensitivity of 60%, specificity of 68%, positive predictive value of 43%, and negative predictive value of 81% in diagnosing strangulated obstruction.
Conclusion
. In present series, D-dimer test was neither sensitive nor specific in diagnosing strangulation.
Keywords: small-bowel obstruction; strangulated obstruction; diagnosis; D-dimer level small-bowel obstruction; strangulated obstruction; diagnosis; D-dimer level
MDPI and ACS Style

Boguševičius, A.; Grinkevičius, A.; Maleckas, A.; Pundzius, J. The role of D-dimer in the diagnosis of strangulated small-bowel obstruction. Medicina 2007, 43, 850.

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