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Medicina is published by MDPI from Volume 54 Issue 1 (2018). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Lithuanian Medical Association, Lithuanian University of Health Sciences, and Vilnius University.
Open AccessArticle

Evaluation of a novel 14C-urea breath test “Heliprobe” in diagnosis of Helicobacter pylori infection

Department of Gastroenterology, Kaunas University of Medicine, Lithuania
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Medicina 2007, 43(1), 32; https://doi.org/10.3390/medicina43010004
Received: 20 March 2006 / Accepted: 18 December 2006 / Published: 23 December 2006
Background. At present, 14C-urea breath test is considered a gold standard for diagnosis of Helicobacter pylori infection, but they are time-consuming, comparably expensive, and usually not portable tests. The aim of our study was to establish the diagnostic value of the novel, inexpensive, quick, and convenient to use 14C-urea breath test “Heliprobe”, Noster AB, Sweden.
Material and methods. Helicobacter pylori testing using “Heliprobe” was performed in 108 consecutive patients. Helicobacter pylori was also investigated using rapid urease test and Giemsa stained histological specimens according to Sydney system.
Results. The diagnostic values of “Heliprobe” assuming the Helicobacter pylori positivity, if the results of two tests (rapid urease test and histology) are positive, were: sensitivity – 97%, specificity – 87%, positive predictive value – 93%, negative predictive value – 95%, accuracy – 94%. The diagnostic values of “Heliprobe” assuming the Helicobacter pylori positivity, if at least the results of one test are positive: sensitivity – 92%, specificity – 100%, positive predictive value – 100%, negative predictive value – 84%, accuracy – 94%.
Conclusions. The novel, quick, convenient to use 14C-urea breath test “Heliprobe” is accurate, reliable, and useful for the diagnosis of Helicobacter pylori infection in routine clinical practice
Keywords: Helicobacter pylori; 14C-urea breath test Helicobacter pylori; 14C-urea breath test
MDPI and ACS Style

Jonaitis, L.V.; Kiudelis, G.; Kupčinskas, L. Evaluation of a novel 14C-urea breath test “Heliprobe” in diagnosis of Helicobacter pylori infection. Medicina 2007, 43, 32.

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